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- W2941003311 abstract "Reconciling the highly tuned and nonlinear basilar membrane (BM) response at the base with the nearly low-pass and weakly nonlinear response at the apex has presented a longstanding challenge to cochlear mechanics modelers. Recent experiments have shown that the BM centric view of cochlear mechanics is incomplete and have highlighted the importance of modeling and measuring the dynamics of the organ of Corti (OoC). Here, we describe a new computational model of the guinea pig cochlea that can correctly simulate the response at all frequencies. The model shows that the electromotile force from the outer hair cells modulate the differential motion between the reticular lamina and the BM. Model calculations at the apex show that the geometric taper of the scalae duct as well as the cytoarchitecture of the OoC breaks the scaling symmetry observed at the base. Further, the model predicts that the neural tuning at the base is primarily governed by the macroscopic dynamics of the cochlear partition, while the micro-scale fluid dynamics and the nano-scale channel dynamics dominate the neural tuning at the apex. Overall, the model provides a physiological explanation for the differences between high and low frequency hearing observed in psychophysical experiments. [Work supported by NIH-R01-04084.]" @default.
- W2941003311 created "2019-05-03" @default.
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- W2941003311 date "2019-03-01" @default.
- W2941003311 modified "2023-10-17" @default.
- W2941003311 title "Nano, micro, and macro-scale effects on cochlear tuning" @default.
- W2941003311 doi "https://doi.org/10.1121/1.5101921" @default.
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