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• W2941004853 abstract "Double-mutant cycle (DMC) analysis is a powerful approach for detecting and quantifying the energetics of both direct and long-range interactions in proteins and other chemical systems. It can also be used to unravel higher-order interactions (e.g. three-body effects) that lead to cooperativity in protein folding and function. In this review, we describe new applications of DMC analysis based on advances in native mass spectrometry and high-throughput methods such as next generation sequencing and protein complementation assays. These developments have facilitated carrying out high-throughput DMC analysis, which can be used to characterize increasingly higher-order interactions and very large interaction networks in proteins. Such studies have provided insights into the extent of cooperativity (epistasis) in protein structures. High-throughput DMC studies have also been used to validate correlated mutation analysis and can provide restraints for protein docking." @default.
• W2941004853 created "2019-05-03" @default.
• W2941004853 creator A5014486140 @default.
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• W2941004853 date "2019-10-01" @default.
• W2941004853 modified "2023-10-16" @default.
• W2941004853 title "Double-mutant cycles: new directions and applications" @default.
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• W2941004853 doi "https://doi.org/10.1016/j.sbi.2019.03.025" @default.
• W2941004853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31029859" @default.
• W2941004853 hasPublicationYear "2019" @default.
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