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- W2941009675 abstract "Research provides valuable information that improves patients’ outcomes and should inform clinical decision-making.1 There are many research methodologies2 and randomised controlled trials (RCTs) are at the top of the hierarchy, providing the most robust results when efficacy of interventions is concerned.3 RCTs are considered the gold standard because randomisation is the best method we have to remove selection bias between two groups of patients. However, to randomise participants in a trials, there has to be genuine uncertainty in the clinicians over whether a treatment will be beneficial.4 This is called clinical equipoise, which provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial.5 Notwithstanding all these considerations, it is well recognised that many RCTs struggle to recruit an adequate sample size, with large, collaborative studies often not being able to meet the targets as originally planned. Difficulty …" @default.
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- W2941009675 date "2019-04-25" @default.
- W2941009675 modified "2023-09-24" @default.
- W2941009675 title "Barriers and incentives to recruitment in mental health clinical trials" @default.
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- W2941009675 doi "https://doi.org/10.1136/ebmental-2019-300090" @default.
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