Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941030182> ?p ?o ?g. }
- W2941030182 endingPage "1307.e16" @default.
- W2941030182 startingPage "1293" @default.
- W2941030182 abstract "The perioculomotor (pIII) region of the midbrain was postulated as a sleep-regulating center in the 1890s but largely neglected in subsequent studies. Using activity-dependent labeling and gene expression profiling, we identified pIII neurons that promote non-rapid eye movement (NREM) sleep. Optrode recording showed that pIII glutamatergic neurons expressing calcitonin gene-related peptide alpha (CALCA) are NREM-sleep active; optogenetic and chemogenetic activation/inactivation showed that they strongly promote NREM sleep. Within the pIII region, CALCA neurons form reciprocal connections with another population of glutamatergic neurons that express the peptide cholecystokinin (CCK). Activation of CCK neurons also promoted NREM sleep. Both CALCA and CCK neurons project rostrally to the preoptic hypothalamus, whereas CALCA neurons also project caudally to the posterior ventromedial medulla. Activation of each projection increased NREM sleep. Together, these findings point to the pIII region as an excitatory sleep center where different subsets of glutamatergic neurons promote NREM sleep through both local reciprocal connections and long-range projections." @default.
- W2941030182 created "2019-05-03" @default.
- W2941030182 creator A5014335552 @default.
- W2941030182 creator A5031279004 @default.
- W2941030182 creator A5035002612 @default.
- W2941030182 creator A5036365985 @default.
- W2941030182 creator A5049815313 @default.
- W2941030182 creator A5052489566 @default.
- W2941030182 creator A5055765486 @default.
- W2941030182 creator A5062315564 @default.
- W2941030182 creator A5071531520 @default.
- W2941030182 creator A5073081816 @default.
- W2941030182 creator A5077282245 @default.
- W2941030182 date "2019-05-01" @default.
- W2941030182 modified "2023-09-27" @default.
- W2941030182 title "An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control" @default.
- W2941030182 cites W1490065438 @default.
- W2941030182 cites W1519578210 @default.
- W2941030182 cites W1896505318 @default.
- W2941030182 cites W1970709955 @default.
- W2941030182 cites W1971248719 @default.
- W2941030182 cites W1980603718 @default.
- W2941030182 cites W1985681303 @default.
- W2941030182 cites W1989776859 @default.
- W2941030182 cites W1992138108 @default.
- W2941030182 cites W1993981485 @default.
- W2941030182 cites W1995433511 @default.
- W2941030182 cites W1999574084 @default.
- W2941030182 cites W2000140223 @default.
- W2941030182 cites W2000816595 @default.
- W2941030182 cites W2012847399 @default.
- W2941030182 cites W2017625070 @default.
- W2941030182 cites W2020346259 @default.
- W2941030182 cites W2032530293 @default.
- W2941030182 cites W2040574649 @default.
- W2941030182 cites W2046300501 @default.
- W2941030182 cites W2047918945 @default.
- W2941030182 cites W2061072142 @default.
- W2941030182 cites W2077244173 @default.
- W2941030182 cites W2080275784 @default.
- W2941030182 cites W2085523626 @default.
- W2941030182 cites W2086338669 @default.
- W2941030182 cites W2086991865 @default.
- W2941030182 cites W2089698459 @default.
- W2941030182 cites W2091860251 @default.
- W2941030182 cites W2095951032 @default.
- W2941030182 cites W2108119444 @default.
- W2941030182 cites W2116717495 @default.
- W2941030182 cites W2117400459 @default.
- W2941030182 cites W2122321125 @default.
- W2941030182 cites W2132320914 @default.
- W2941030182 cites W2143449404 @default.
- W2941030182 cites W2145357804 @default.
- W2941030182 cites W2150626351 @default.
- W2941030182 cites W2152103038 @default.
- W2941030182 cites W2161853532 @default.
- W2941030182 cites W2164153190 @default.
- W2941030182 cites W2164826784 @default.
- W2941030182 cites W2167495346 @default.
- W2941030182 cites W2208160033 @default.
- W2941030182 cites W2213750320 @default.
- W2941030182 cites W2216165351 @default.
- W2941030182 cites W2239211889 @default.
- W2941030182 cites W2317902632 @default.
- W2941030182 cites W2402763080 @default.
- W2941030182 cites W2509318050 @default.
- W2941030182 cites W2527794060 @default.
- W2941030182 cites W2537955564 @default.
- W2941030182 cites W2551360963 @default.
- W2941030182 cites W2616271045 @default.
- W2941030182 cites W2742805202 @default.
- W2941030182 cites W2746403472 @default.
- W2941030182 cites W2758946206 @default.
- W2941030182 cites W2762801453 @default.
- W2941030182 cites W2765605017 @default.
- W2941030182 cites W2783832094 @default.
- W2941030182 cites W2796596122 @default.
- W2941030182 cites W2804381908 @default.
- W2941030182 cites W2883713442 @default.
- W2941030182 cites W2905176374 @default.
- W2941030182 doi "https://doi.org/10.1016/j.cell.2019.03.041" @default.
- W2941030182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31031008" @default.
- W2941030182 hasPublicationYear "2019" @default.
- W2941030182 type Work @default.
- W2941030182 sameAs 2941030182 @default.
- W2941030182 citedByCount "49" @default.
- W2941030182 countsByYear W29410301822019 @default.
- W2941030182 countsByYear W29410301822020 @default.
- W2941030182 countsByYear W29410301822021 @default.
- W2941030182 countsByYear W29410301822022 @default.
- W2941030182 countsByYear W29410301822023 @default.
- W2941030182 crossrefType "journal-article" @default.
- W2941030182 hasAuthorship W2941030182A5014335552 @default.
- W2941030182 hasAuthorship W2941030182A5031279004 @default.
- W2941030182 hasAuthorship W2941030182A5035002612 @default.
- W2941030182 hasAuthorship W2941030182A5036365985 @default.
- W2941030182 hasAuthorship W2941030182A5049815313 @default.
- W2941030182 hasAuthorship W2941030182A5052489566 @default.