FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941192500> ?p ?o ?g. }

• W2941192500 abstract "Astrocytes are essential partners for neurons and their role in Huntington’s disease (HD) is emerging. In HD, astrocytes change and become reactive. Astrocyte reactivity is characterized by morphological changes but its functional impact is still unclear. To understand the roles of reactive astrocytes in HD, we have developed viral vectors that infect selectively astrocytes in vivo and either block or induce reactivity, through manipulation of the JAK2-STAT3 pathway. We used these vectors to modulate astrocyte reactivity in two complementary mouse models of HD [knock-in Hdh140 mice and lentivirus-mediated expression of a fragment of mutated Huntingtin (mHtt) in striatal neurons]. In these two models, we found that reactive astrocytes decrease the number and size of mHtt aggregates. How can reactive astrocytes reduce the aggregation of mHtt within neurons? We performed whole-genome transcriptomic analysis of acutely sorted reactive astrocytes to identify genes regulated by the JAK2-STAT3 pathway in astrocytes. We found an enrichment in genes linked to autophagy-lysosome and ubiquitin-proteasome systems, suggesting that reactive astrocytes have an enhanced capacity for protein degradation and could siphon mHtt away from neurons. Moreover, we identified several chaperones upregulated in reactive astrocytes. Chaperones prevent protein aggregation and can be released extracellularly. They could reduce mHtt aggregation within neurons themselves. Our data show that astrocytes develop a protective response in HD that involves bidirectional signaling with neurons to reduce mHtt aggregation. Reactive astrocytes are not only defective cells as usually reported, but also acquire enhanced capacities to promote mHtt clearance, which has strong therapeutic relevance for HD." @default.
• W2941192500 created "2019-05-03" @default.
• W2941192500 creator A5004430637 @default.
• W2941192500 creator A5013839554 @default.
• W2941192500 creator A5019346214 @default.
• W2941192500 creator A5023363225 @default.
• W2941192500 creator A5024251772 @default.
• W2941192500 creator A5024687365 @default.
• W2941192500 creator A5025047591 @default.
• W2941192500 creator A5026093103 @default.
• W2941192500 creator A5039267078 @default.
• W2941192500 creator A5040501446 @default.
• W2941192500 creator A5043094295 @default.
• W2941192500 creator A5047173784 @default.
• W2941192500 creator A5049067226 @default.
• W2941192500 creator A5049107218 @default.
• W2941192500 creator A5051377002 @default.
• W2941192500 creator A5065418218 @default.
• W2941192500 creator A5067657844 @default.
• W2941192500 creator A5089008618 @default.
• W2941192500 date "2018-09-01" @default.
• W2941192500 modified "2023-09-24" @default.
• W2941192500 title "A42 Reactive astrocytes promote proteostasis in huntington’s disease" @default.
• W2941192500 doi "https://doi.org/10.1136/jnnp-2018-ehdn.40" @default.
• W2941192500 hasPublicationYear "2018" @default.
• W2941192500 type Work @default.
• W2941192500 sameAs 2941192500 @default.
• W2941192500 citedByCount "1" @default.
• W2941192500 countsByYear W29411925002020 @default.
• W2941192500 crossrefType "proceedings-article" @default.
• W2941192500 hasAuthorship W2941192500A5004430637 @default.
• W2941192500 hasAuthorship W2941192500A5013839554 @default.
• W2941192500 hasAuthorship W2941192500A5019346214 @default.
• W2941192500 hasAuthorship W2941192500A5023363225 @default.
• W2941192500 hasAuthorship W2941192500A5024251772 @default.
• W2941192500 hasAuthorship W2941192500A5024687365 @default.
• W2941192500 hasAuthorship W2941192500A5025047591 @default.
• W2941192500 hasAuthorship W2941192500A5026093103 @default.
• W2941192500 hasAuthorship W2941192500A5039267078 @default.
• W2941192500 hasAuthorship W2941192500A5040501446 @default.
• W2941192500 hasAuthorship W2941192500A5043094295 @default.
• W2941192500 hasAuthorship W2941192500A5047173784 @default.
• W2941192500 hasAuthorship W2941192500A5049067226 @default.
• W2941192500 hasAuthorship W2941192500A5049107218 @default.
• W2941192500 hasAuthorship W2941192500A5051377002 @default.
• W2941192500 hasAuthorship W2941192500A5065418218 @default.
• W2941192500 hasAuthorship W2941192500A5067657844 @default.
• W2941192500 hasAuthorship W2941192500A5089008618 @default.
• W2941192500 hasConcept C104317684 @default.
• W2941192500 hasConcept C142724271 @default.
• W2941192500 hasConcept C143065580 @default.
• W2941192500 hasConcept C169760540 @default.
• W2941192500 hasConcept C181199279 @default.
• W2941192500 hasConcept C185592680 @default.
• W2941192500 hasConcept C2776925932 @default.
• W2941192500 hasConcept C2777542381 @default.
• W2941192500 hasConcept C2779134260 @default.
• W2941192500 hasConcept C2780216420 @default.
• W2941192500 hasConcept C2781427258 @default.
• W2941192500 hasConcept C2781452922 @default.
• W2941192500 hasConcept C529278444 @default.
• W2941192500 hasConcept C55493867 @default.
• W2941192500 hasConcept C71924100 @default.
• W2941192500 hasConcept C86803240 @default.
• W2941192500 hasConcept C95444343 @default.
• W2941192500 hasConceptScore W2941192500C104317684 @default.
• W2941192500 hasConceptScore W2941192500C142724271 @default.
• W2941192500 hasConceptScore W2941192500C143065580 @default.
• W2941192500 hasConceptScore W2941192500C169760540 @default.
• W2941192500 hasConceptScore W2941192500C181199279 @default.
• W2941192500 hasConceptScore W2941192500C185592680 @default.
• W2941192500 hasConceptScore W2941192500C2776925932 @default.
• W2941192500 hasConceptScore W2941192500C2777542381 @default.
• W2941192500 hasConceptScore W2941192500C2779134260 @default.
• W2941192500 hasConceptScore W2941192500C2780216420 @default.
• W2941192500 hasConceptScore W2941192500C2781427258 @default.
• W2941192500 hasConceptScore W2941192500C2781452922 @default.
• W2941192500 hasConceptScore W2941192500C529278444 @default.
• W2941192500 hasConceptScore W2941192500C55493867 @default.
• W2941192500 hasConceptScore W2941192500C71924100 @default.
• W2941192500 hasConceptScore W2941192500C86803240 @default.
• W2941192500 hasConceptScore W2941192500C95444343 @default.
• W2941192500 hasLocation W29411925001 @default.
• W2941192500 hasOpenAccess W2941192500 @default.
• W2941192500 hasPrimaryLocation W29411925001 @default.
• W2941192500 hasRelatedWork W2018342821 @default.
• W2941192500 hasRelatedWork W2041940338 @default.
• W2941192500 hasRelatedWork W2326213169 @default.
• W2941192500 hasRelatedWork W2497712933 @default.
• W2941192500 hasRelatedWork W2560036785 @default.
• W2941192500 hasRelatedWork W2702180170 @default.
• W2941192500 hasRelatedWork W2748254120 @default.
• W2941192500 hasRelatedWork W2762335503 @default.
• W2941192500 hasRelatedWork W2768176473 @default.
• W2941192500 hasRelatedWork W2896171397 @default.
• W2941192500 hasRelatedWork W2900388279 @default.
• W2941192500 hasRelatedWork W2942386241 @default.
• W2941192500 hasRelatedWork W2966348819 @default.
• W2941192500 hasRelatedWork W2977458015 @default.
• W2941192500 hasRelatedWork W2992374490 @default.

• next