Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941285087> ?p ?o ?g. }
- W2941285087 abstract "Axons convey information in neuronal circuits via reliable conduction of action potentials (APs) from the axon initial segment (AIS) to the presynaptic terminals. Recent experimental findings increasingly evidence that the axonal function is not limited to the simple transmission of APs. Advances in subcellular-resolution recording techniques have shown that axons display activity-dependent modulation in spike shape and conduction velocity, which influence synaptic strength and latency. We briefly review here, how recent methodological developments facilitate the understanding of the axon physiology. We included the three most common methods, i.e., genetically encoded voltage imaging (GEVI), subcellular patch-clamp and high-density microelectrode arrays (HD-MEAs). We then describe the potential of using HD-MEAs in studying axonal physiology in more detail. Due to their robustness, amenability to high-throughput and high spatiotemporal resolution, HD-MEAs can provide a direct functional electrical readout of single cells and cellular ensembles at subcellular resolution. HD-MEAs can, therefore, be employed in investigating axonal pathologies, the effects of large-scale genomic interventions (e.g., with RNAi or CRISPR) or in compound screenings. A combination of extracellular microelectrode arrays (MEAs), intracellular microelectrodes and optical imaging may potentially reveal yet unexplored repertoires of axonal functions." @default.
- W2941285087 created "2019-05-03" @default.
- W2941285087 creator A5000470100 @default.
- W2941285087 creator A5025870532 @default.
- W2941285087 creator A5056654865 @default.
- W2941285087 creator A5089452879 @default.
- W2941285087 date "2019-04-26" @default.
- W2941285087 modified "2023-10-12" @default.
- W2941285087 title "Technologies to Study Action Potential Propagation With a Focus on HD-MEAs" @default.
- W2941285087 cites W1517737501 @default.
- W2941285087 cites W1527505950 @default.
- W2941285087 cites W1552650364 @default.
- W2941285087 cites W1832906682 @default.
- W2941285087 cites W1907563648 @default.
- W2941285087 cites W1969277140 @default.
- W2941285087 cites W1971449558 @default.
- W2941285087 cites W1971880089 @default.
- W2941285087 cites W1973275441 @default.
- W2941285087 cites W1975656737 @default.
- W2941285087 cites W1976351814 @default.
- W2941285087 cites W1979400171 @default.
- W2941285087 cites W1980956223 @default.
- W2941285087 cites W1982277188 @default.
- W2941285087 cites W1982548160 @default.
- W2941285087 cites W1983634702 @default.
- W2941285087 cites W1987345946 @default.
- W2941285087 cites W1992718402 @default.
- W2941285087 cites W2000256732 @default.
- W2941285087 cites W2001631200 @default.
- W2941285087 cites W2002812952 @default.
- W2941285087 cites W2006524711 @default.
- W2941285087 cites W2009604140 @default.
- W2941285087 cites W2012930819 @default.
- W2941285087 cites W2016789142 @default.
- W2941285087 cites W2022659970 @default.
- W2941285087 cites W2023148260 @default.
- W2941285087 cites W2026957732 @default.
- W2941285087 cites W2028226828 @default.
- W2941285087 cites W2029565084 @default.
- W2941285087 cites W2035327540 @default.
- W2941285087 cites W2037088482 @default.
- W2941285087 cites W2039623701 @default.
- W2941285087 cites W2039804216 @default.
- W2941285087 cites W2040793024 @default.
- W2941285087 cites W2044695449 @default.
- W2941285087 cites W2046508203 @default.
- W2941285087 cites W2046809895 @default.
- W2941285087 cites W2048635483 @default.
- W2941285087 cites W2055241344 @default.
- W2941285087 cites W2057628845 @default.
- W2941285087 cites W2058858982 @default.
- W2941285087 cites W2059149310 @default.
- W2941285087 cites W2060107355 @default.
- W2941285087 cites W2062382534 @default.
- W2941285087 cites W2063536600 @default.
- W2941285087 cites W2063594532 @default.
- W2941285087 cites W2066734670 @default.
- W2941285087 cites W2069950623 @default.
- W2941285087 cites W2070996711 @default.
- W2941285087 cites W2071365886 @default.
- W2941285087 cites W2074413930 @default.
- W2941285087 cites W2075437459 @default.
- W2941285087 cites W2076550589 @default.
- W2941285087 cites W2084344892 @default.
- W2941285087 cites W2086373463 @default.
- W2941285087 cites W2087732286 @default.
- W2941285087 cites W2103090901 @default.
- W2941285087 cites W2104159920 @default.
- W2941285087 cites W2105609812 @default.
- W2941285087 cites W2110402020 @default.
- W2941285087 cites W2112736669 @default.
- W2941285087 cites W2116336142 @default.
- W2941285087 cites W2122227532 @default.
- W2941285087 cites W2123556420 @default.
- W2941285087 cites W2124486024 @default.
- W2941285087 cites W2125761630 @default.
- W2941285087 cites W2128432504 @default.
- W2941285087 cites W2129229909 @default.
- W2941285087 cites W2131301953 @default.
- W2941285087 cites W2132690090 @default.
- W2941285087 cites W2134561320 @default.
- W2941285087 cites W2137393514 @default.
- W2941285087 cites W2139782195 @default.
- W2941285087 cites W2140480932 @default.
- W2941285087 cites W2145527534 @default.
- W2941285087 cites W2145909957 @default.
- W2941285087 cites W2147372985 @default.
- W2941285087 cites W2150013393 @default.
- W2941285087 cites W2154616351 @default.
- W2941285087 cites W2157249610 @default.
- W2941285087 cites W2160497177 @default.
- W2941285087 cites W2160880533 @default.
- W2941285087 cites W2160980290 @default.
- W2941285087 cites W2164507911 @default.
- W2941285087 cites W2167095271 @default.
- W2941285087 cites W2168254795 @default.
- W2941285087 cites W2170921124 @default.
- W2941285087 cites W2176803657 @default.
- W2941285087 cites W2180930892 @default.
- W2941285087 cites W2202139434 @default.