FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941344810> ?p ?o ?g. }

• W2941344810 abstract "One of the questions in the design of cancer clinical trials with combination of two drugs is in which order to administer the drugs. This is an important question, especially in the case where one agent may interfere with the effectiveness of the other agent. In the present paper we develop a mathematical model to address this scheduling question in a specific case where one of the drugs is anti-VEGF, which is known to affect the perfusion of other drugs. As a second drug we take anti-PD-1. Both drugs are known to increase the activation of anticancer T cells. Our simulations show that in the case where anti-VEGF reduces the perfusion, a non-overlapping schedule is significantly more effective than a simultaneous injection of the two drugs, and it is somewhat more beneficial to inject anti-PD-1 first. The method and results of the paper can be extended to other combinations, and they could play an important role in the design of clinical trials with combination therapy, where scheduling strategies may significantly affect the outcome." @default.
• W2941344810 created "2019-05-03" @default.
• W2941344810 creator A5027260022 @default.
• W2941344810 creator A5033033981 @default.
• W2941344810 date "2019-03-13" @default.
• W2941344810 modified "2023-09-30" @default.
• W2941344810 title "How to schedule VEGF and PD-1 inhibitors in combination cancer therapy?" @default.
• W2941344810 cites W1518184777 @default.
• W2941344810 cites W1823780969 @default.
• W2941344810 cites W1834409279 @default.
• W2941344810 cites W1893566975 @default.
• W2941344810 cites W1963851958 @default.
• W2941344810 cites W1964871165 @default.
• W2941344810 cites W1977735548 @default.
• W2941344810 cites W1978541343 @default.
• W2941344810 cites W1986141346 @default.
• W2941344810 cites W1997388726 @default.
• W2941344810 cites W1997851555 @default.
• W2941344810 cites W2000346327 @default.
• W2941344810 cites W2012852444 @default.
• W2941344810 cites W2013520562 @default.
• W2941344810 cites W2018595535 @default.
• W2941344810 cites W2022562553 @default.
• W2941344810 cites W2041441588 @default.
• W2941344810 cites W2050216284 @default.
• W2941344810 cites W2062783581 @default.
• W2941344810 cites W2069496194 @default.
• W2941344810 cites W2077360194 @default.
• W2941344810 cites W2077630473 @default.
• W2941344810 cites W2078643379 @default.
• W2941344810 cites W2088571368 @default.
• W2941344810 cites W2102282878 @default.
• W2941344810 cites W2103335284 @default.
• W2941344810 cites W2106949373 @default.
• W2941344810 cites W2112154408 @default.
• W2941344810 cites W2129482327 @default.
• W2941344810 cites W2130883177 @default.
• W2941344810 cites W2137626178 @default.
• W2941344810 cites W2140264799 @default.
• W2941344810 cites W2142579810 @default.
• W2941344810 cites W2143512985 @default.
• W2941344810 cites W2143594415 @default.
• W2941344810 cites W2144893998 @default.
• W2941344810 cites W2146099965 @default.
• W2941344810 cites W2150544967 @default.
• W2941344810 cites W2150654884 @default.
• W2941344810 cites W2152803686 @default.
• W2941344810 cites W2152948584 @default.
• W2941344810 cites W2154670252 @default.
• W2941344810 cites W2156906256 @default.
• W2941344810 cites W2161261098 @default.
• W2941344810 cites W2166918177 @default.
• W2941344810 cites W2171172959 @default.
• W2941344810 cites W2171676198 @default.
• W2941344810 cites W2179115666 @default.
• W2941344810 cites W2196610251 @default.
• W2941344810 cites W2339025832 @default.
• W2941344810 cites W2466587221 @default.
• W2941344810 cites W2473347405 @default.
• W2941344810 cites W2511951051 @default.
• W2941344810 cites W2556495987 @default.
• W2941344810 cites W2604391908 @default.
• W2941344810 cites W2607357764 @default.
• W2941344810 cites W2619891302 @default.
• W2941344810 cites W2737025620 @default.
• W2941344810 cites W2981647581 @default.
• W2941344810 cites W4213281733 @default.
• W2941344810 doi "https://doi.org/10.1186/s12918-019-0706-y" @default.
• W2941344810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6427900" @default.
• W2941344810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30894166" @default.
• W2941344810 hasPublicationYear "2019" @default.
• W2941344810 type Work @default.
• W2941344810 sameAs 2941344810 @default.
• W2941344810 citedByCount "15" @default.
• W2941344810 countsByYear W29413448102020 @default.
• W2941344810 countsByYear W29413448102021 @default.
• W2941344810 countsByYear W29413448102022 @default.
• W2941344810 countsByYear W29413448102023 @default.
• W2941344810 crossrefType "journal-article" @default.
• W2941344810 hasAuthorship W2941344810A5027260022 @default.
• W2941344810 hasAuthorship W2941344810A5033033981 @default.
• W2941344810 hasBestOaLocation W29413448101 @default.
• W2941344810 hasConcept C111919701 @default.
• W2941344810 hasConcept C112930515 @default.
• W2941344810 hasConcept C121608353 @default.
• W2941344810 hasConcept C126255220 @default.
• W2941344810 hasConcept C126322002 @default.
• W2941344810 hasConcept C167734588 @default.
• W2941344810 hasConcept C177713679 @default.
• W2941344810 hasConcept C206729178 @default.
• W2941344810 hasConcept C2776999253 @default.
• W2941344810 hasConcept C2780035454 @default.
• W2941344810 hasConcept C2983331546 @default.
• W2941344810 hasConcept C33923547 @default.
• W2941344810 hasConcept C41008148 @default.
• W2941344810 hasConcept C502942594 @default.
• W2941344810 hasConcept C535046627 @default.
• W2941344810 hasConcept C68387754 @default.
• W2941344810 hasConcept C71924100 @default.
• W2941344810 hasConcept C98274493 @default.

• next