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• W2941372839 abstract "The aim of this study was to investigate the time- and dose-dependency of DNA double-strand break (DSB) induction and repair in peripheral blood leucocytes of prostate cancer patients during therapy with 177Lu-PSMA.Blood samples from 16 prostate cancer patients receiving their first 177Lu-PSMA therapy were taken before and at seven time-points (between 1 h and 96 h) after radionuclide administration. Absorbed doses to the blood were calculated using integrated time-activity curves of the blood and the whole-body. For DSB quantification, leucocytes were isolated, fixed in ethanol and immunostained with γ-H2AX and 53BP1 antibodies. Colocalizing foci of both DSB markers were manually counted in a fluorescence microscope.The average number of radiation-induced foci (RIF) per cell increased within the first 4 h after administration, followed by a decrease indicating DNA repair. The number of RIF during the first 2.6 h correlated linearly with the absorbed dose to the blood (R2 = 0.58), in good agreement with previously published in-vitro data. At late time-points (48 h and 96 h after administration), the number of RIF correlated linearly with the absorbed dose rate (R2 = 0.56). In most patients, DNA DSBs were repaired effectively. However, in some patients RIF did not disappear completely even 96 h after administration.The general pattern of the time- and dose-dependent induction and disappearance of RIF during 177Lu-PSMA therapy is similar to that of other radionuclide therapies." @default.
• W2941372839 created "2019-05-03" @default.
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• W2941372839 date "2019-04-27" @default.
• W2941372839 modified "2023-10-15" @default.
• W2941372839 title "DNA damage in blood leucocytes of prostate cancer patients during therapy with 177Lu-PSMA" @default.
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• W2941372839 doi "https://doi.org/10.1007/s00259-019-04317-4" @default.
• W2941372839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6584247" @default.
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