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- W2941395492 abstract "Meiosis produces gametes through a specialized, two-step cell division, which is highly error prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where sister chromatids separate. Uniquely during meiosis I, sister kinetochores are monooriented and pericentromeric cohesin is protected. Here, we demonstrate that these key adaptations for reductional chromosome segregation are achieved through separable control of multiple kinases by the meiosis-I-specific budding yeast Spo13 protein. Recruitment of Polo kinase to kinetochores directs monoorientation, while independently, cohesin protection is achieved by containing the effects of cohesin kinases. Therefore, reductional chromosome segregation, the defining feature of meiosis, is established by multifaceted kinase control by a master regulator. The recent identification of Spo13 orthologs, fission yeast Moa1 and mouse MEIKIN, suggests that kinase coordination by a meiosis I regulator may be a general feature in the establishment of reductional chromosome segregation." @default.
- W2941395492 created "2019-05-03" @default.
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- W2941395492 date "2019-05-01" @default.
- W2941395492 modified "2023-10-14" @default.
- W2941395492 title "Reductional Meiosis I Chromosome Segregation Is Established by Coordination of Key Meiotic Kinases" @default.
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- W2941395492 doi "https://doi.org/10.1016/j.devcel.2019.04.003" @default.
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