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- W2941417604 abstract "The human genetic code is the vehicle that drives the synthesis of proteins necessary for life-sustaining biological processes. Though the genetic ciphering remains unchanged through generations, some genes get disrupted, deleted and/or mutated, manifested as diseases and disorders. Current treatment options—chemotherapy, protein therapy, radiotherapy, and surgery available for less than 500 diseases—neither cure nor prevent genetic errors, but rather, often cause many side effects. However, gene therapy, colloquially called “living drug,” provides a one-time treatment option by rewriting or fixing errors in the natural genetic ciphering. Since gene therapy is predominantly a viral vector-based medicine, it has met with a fair bit of skepticism from both the science fraternity and patients. Now, thanks to advancements in gene editing and recombinant viral vector development, the interest of clinicians and pharmaceutical industries has been rekindled. With the advent of more than 12 different gene therapy drugs for curing cancer, blindness, immune, and neuronal disorders, this emerging experimental medical treatment has yet again come in the limelight. The present review article delves into the popular viral vectors used in gene therapy, advances, challenges, and perspectives." @default.
- W2941417604 created "2019-05-03" @default.
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- W2941417604 date "2019-04-24" @default.
- W2941417604 modified "2023-10-18" @default.
- W2941417604 title "Gene Therapy Leaves a Vicious Cycle" @default.
- W2941417604 cites W1070515499 @default.
- W2941417604 cites W1493553959 @default.
- W2941417604 cites W1518729035 @default.
- W2941417604 cites W1554330891 @default.
- W2941417604 cites W1557780170 @default.
- W2941417604 cites W1586130277 @default.
- W2941417604 cites W1616824889 @default.
- W2941417604 cites W1697401014 @default.
- W2941417604 cites W1808026750 @default.
- W2941417604 cites W1833520300 @default.
- W2941417604 cites W1857650329 @default.
- W2941417604 cites W1902159756 @default.
- W2941417604 cites W191504613 @default.
- W2941417604 cites W1925829306 @default.
- W2941417604 cites W1964221220 @default.
- W2941417604 cites W1968006472 @default.
- W2941417604 cites W1968283357 @default.
- W2941417604 cites W1969271703 @default.
- W2941417604 cites W1969274892 @default.
- W2941417604 cites W1969874649 @default.
- W2941417604 cites W1970221854 @default.
- W2941417604 cites W1970668112 @default.
- W2941417604 cites W1971014753 @default.
- W2941417604 cites W1971163950 @default.
- W2941417604 cites W1971656628 @default.
- W2941417604 cites W1973362947 @default.
- W2941417604 cites W1981930894 @default.
- W2941417604 cites W1982220916 @default.
- W2941417604 cites W1984714304 @default.
- W2941417604 cites W1985770934 @default.
- W2941417604 cites W1989960888 @default.
- W2941417604 cites W1991928755 @default.
- W2941417604 cites W1995484601 @default.
- W2941417604 cites W1996530389 @default.
- W2941417604 cites W2003279028 @default.
- W2941417604 cites W2003955696 @default.
- W2941417604 cites W2007129827 @default.
- W2941417604 cites W2007261697 @default.
- W2941417604 cites W2008033906 @default.
- W2941417604 cites W2008289270 @default.
- W2941417604 cites W2010666698 @default.
- W2941417604 cites W2012041157 @default.
- W2941417604 cites W2012134426 @default.
- W2941417604 cites W2014850190 @default.
- W2941417604 cites W2015159733 @default.
- W2941417604 cites W2015870495 @default.
- W2941417604 cites W2016714875 @default.
- W2941417604 cites W2017248525 @default.
- W2941417604 cites W2018849311 @default.
- W2941417604 cites W2022161423 @default.
- W2941417604 cites W2025177940 @default.
- W2941417604 cites W2026022524 @default.
- W2941417604 cites W2027336444 @default.
- W2941417604 cites W2028068823 @default.
- W2941417604 cites W2028266585 @default.
- W2941417604 cites W2029926937 @default.
- W2941417604 cites W2030464507 @default.
- W2941417604 cites W2033005054 @default.
- W2941417604 cites W2035894198 @default.
- W2941417604 cites W2037639054 @default.
- W2941417604 cites W2039551908 @default.
- W2941417604 cites W2041612363 @default.
- W2941417604 cites W2045343535 @default.
- W2941417604 cites W2049735665 @default.
- W2941417604 cites W2050649932 @default.
- W2941417604 cites W2050796131 @default.
- W2941417604 cites W2051159468 @default.
- W2941417604 cites W2051186727 @default.
- W2941417604 cites W2051958360 @default.
- W2941417604 cites W2054174437 @default.
- W2941417604 cites W2056074289 @default.
- W2941417604 cites W2056602419 @default.
- W2941417604 cites W2057548071 @default.
- W2941417604 cites W2061002044 @default.
- W2941417604 cites W2061223273 @default.
- W2941417604 cites W2062756228 @default.
- W2941417604 cites W2064901086 @default.
- W2941417604 cites W2065633718 @default.
- W2941417604 cites W2066696534 @default.
- W2941417604 cites W2069494011 @default.
- W2941417604 cites W2070614858 @default.
- W2941417604 cites W2070780294 @default.
- W2941417604 cites W2071367065 @default.
- W2941417604 cites W2076829876 @default.
- W2941417604 cites W2077387683 @default.