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• W2941466069 abstract "You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction III (PD65)1 Apr 2019PD65-11 NOCTURNAL DIURESIS RATE PATTERNS IN NOCTURNAL POLYURIA SYNDROME AND SECONDARY NOCTURNAL POLYURIA Matthew Epstein*, Thomas Monaghan, Kyle Michaelson, Zhan Wu, Nicholas Suss, Arturo Holmes, Donald Bliwise, Jason Lazar, and Jeffrey Weiss Matthew Epstein*Matthew Epstein* More articles by this author , Thomas MonaghanThomas Monaghan More articles by this author , Kyle MichaelsonKyle Michaelson More articles by this author , Zhan WuZhan Wu More articles by this author , Nicholas SussNicholas Suss More articles by this author , Arturo HolmesArturo Holmes More articles by this author , Donald BliwiseDonald Bliwise More articles by this author , Jason LazarJason Lazar More articles by this author , and Jeffrey WeissJeffrey Weiss More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557461.86043.53AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: In this study, we investigate how nocturnal diuresis rates differ at different portions of sleep for 5 different etiologies of nocturnal polyuria (NP) to aid in identifying optimal management strategies for the distinct clinical entities of NP. METHODS: We retrospectively analyzed a database of voiding diaries from patients managed for nocturia at a Veterans Affairs urology clinic from 2007-2018. The first complete entries were included for males aged ≥18 with clinically-significant nocturia (≥2 nocturnal voids) owing to NP using the two most common definitions of NP: nocturnal urine production [NUP] ≥90 mL/h and nocturnal polyuria index [NPi] ≥0.33. Patients meeting criteria were divided into 5 sub-groups with a single diagnosis of either Nocturnal Polyuria Syndrome (NPS), diabetes insipidus (DI), obstructive sleep apnea (OSA), congestive heart failure (CHF), and chronic kidney disease (CKD). NPS was defined as NP in the absence of all aforementioned diagnoses. Early nocturnal diuresis rate (ENDR), defined as first nocturnal voided volume/first uninterrupted sleep period, late nocturnal diuresis rate (LNDR), defined as remaining nocturnal urine volume/remaining hours of sleep, and diurnal diuresis rate (DDR), defined as daytime urine volume/hours awake, were calculated and displayed with Wilcoxon confidence intervals in Figure 1. RESULTS: At both NUP ≥90 mL/h and NPi ≥0.33, patients with NPS demonstrated an increase in diuresis rate during the early portion of sleep, followed by a decline in the latter portion of sleep, which followed the same pattern for patients with DI with NP defined as NUP ≥90 mL/h. Only 1 patient was identified with DI and NP defined as NPi ≥0.33 following inclusion and exclusion criteria. At both NUP ≥90mL/h and NPi ≥0.33, patients with OSA, CHF, and CKD were observed to have a gradual increase in diuresis rate from early nocturnal to the late nocturnal period. CONCLUSIONS: Patients with NPS and DI exhibited an early nocturnal surge in diuresis rate, followed by a decline in the latter portion of sleep. In contrast, patients with NP of cardiogenic and renal etiology displayed a gradual increase in diuresis rate from the early to latter portion of sleep. Nocturia interventions may vary according to the differing underlying mechanisms in these subtypes of nocturnal polyuria. Source of Funding: none Brooklyn, NY; Atlanta, GA; Brooklyn, NY© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e1191-e1191 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Matthew Epstein* More articles by this author Thomas Monaghan More articles by this author Kyle Michaelson More articles by this author Zhan Wu More articles by this author Nicholas Suss More articles by this author Arturo Holmes More articles by this author Donald Bliwise More articles by this author Jason Lazar More articles by this author Jeffrey Weiss More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2941466069 date "2019-04-01" @default.
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• W2941466069 title "PD65-11 NOCTURNAL DIURESIS RATE PATTERNS IN NOCTURNAL POLYURIA SYNDROME AND SECONDARY NOCTURNAL POLYURIA" @default.
• W2941466069 doi "https://doi.org/10.1097/01.ju.0000557461.86043.53" @default.
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