Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941492008> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2941492008 abstract "Klebsiella pneumoniae (Kp) is an infamous cause of multi-drug resistant (MDR) healthcare-associated infections and several MDR clones are globally distributed. A small number of drug-susceptible clones have also become globally distributed, causing severe community-acquired infections. These ‘hypervirulent’ clones are distinguished by expression of highly serum-resistant K1/K2 capsules, plus high prevalence of acquired virulence determinants. While hypervirulence and drug resistance are usually mutually exclusive, there are now increasing reports of convergent strains that are both highly virulent and MDR – a potentially disastrous combination. To better understand the risks of MDR-virulence convergence, we leveraged a collection of >2200 Kp genomes to identify 28 common clones (n≥10 genomes each), and performed a genomic evolutionary comparison. Eight MDR and 6 hypervirulent clones were identified by acquired resistance and virulence gene prevalence. Chromosomal recombination, capsule locus diversity, pan-genome, plasmid and phage dynamics were compared. MDR clones were highly diverse, with frequent chromosomal recombination generating extensive capsule locus diversity. Additional pan-genome diversity was driven by frequent acquisition/loss of both plasmids and phage. In contrast, chromosomal recombination was rare in the hypervirulent clones, which were each associated with only a single capsule locus and showed significant reduction in pan-genome diversity, largely driven by a reduction in plasmid diversity. These data suggest that hypervirulent clones are subject to some sort of constraint for horizontal gene-transfer. Hence we predict MDR clones pose the greatest risk for MDR-virulence convergence because they are more likely to acquire virulence genes than hypervirulent clones are to acquire resistance genes." @default.
- W2941492008 created "2019-05-03" @default.
- W2941492008 creator A5001563532 @default.
- W2941492008 creator A5002168518 @default.
- W2941492008 creator A5003813203 @default.
- W2941492008 creator A5019438141 @default.
- W2941492008 creator A5030993787 @default.
- W2941492008 creator A5040568953 @default.
- W2941492008 creator A5051736895 @default.
- W2941492008 creator A5052479264 @default.
- W2941492008 creator A5082498266 @default.
- W2941492008 creator A5087822392 @default.
- W2941492008 date "2019-03-01" @default.
- W2941492008 modified "2023-09-27" @default.
- W2941492008 title "Genomic evolution of Klebsiella pneumoniae clones: the good, the bad and the ugly" @default.
- W2941492008 doi "https://doi.org/10.1099/acmi.ac2019.po0306" @default.
- W2941492008 hasPublicationYear "2019" @default.
- W2941492008 type Work @default.
- W2941492008 sameAs 2941492008 @default.
- W2941492008 citedByCount "1" @default.
- W2941492008 countsByYear W29414920082023 @default.
- W2941492008 crossrefType "journal-article" @default.
- W2941492008 hasAuthorship W2941492008A5001563532 @default.
- W2941492008 hasAuthorship W2941492008A5002168518 @default.
- W2941492008 hasAuthorship W2941492008A5003813203 @default.
- W2941492008 hasAuthorship W2941492008A5019438141 @default.
- W2941492008 hasAuthorship W2941492008A5030993787 @default.
- W2941492008 hasAuthorship W2941492008A5040568953 @default.
- W2941492008 hasAuthorship W2941492008A5051736895 @default.
- W2941492008 hasAuthorship W2941492008A5052479264 @default.
- W2941492008 hasAuthorship W2941492008A5082498266 @default.
- W2941492008 hasAuthorship W2941492008A5087822392 @default.
- W2941492008 hasBestOaLocation W29414920081 @default.
- W2941492008 hasConcept C102744134 @default.
- W2941492008 hasConcept C104317684 @default.
- W2941492008 hasConcept C141231307 @default.
- W2941492008 hasConcept C144024400 @default.
- W2941492008 hasConcept C149923435 @default.
- W2941492008 hasConcept C22744801 @default.
- W2941492008 hasConcept C2777058267 @default.
- W2941492008 hasConcept C2908647359 @default.
- W2941492008 hasConcept C54355233 @default.
- W2941492008 hasConcept C547475151 @default.
- W2941492008 hasConcept C60987743 @default.
- W2941492008 hasConcept C81977670 @default.
- W2941492008 hasConcept C84597430 @default.
- W2941492008 hasConcept C86803240 @default.
- W2941492008 hasConcept C89423630 @default.
- W2941492008 hasConcept C92938381 @default.
- W2941492008 hasConceptScore W2941492008C102744134 @default.
- W2941492008 hasConceptScore W2941492008C104317684 @default.
- W2941492008 hasConceptScore W2941492008C141231307 @default.
- W2941492008 hasConceptScore W2941492008C144024400 @default.
- W2941492008 hasConceptScore W2941492008C149923435 @default.
- W2941492008 hasConceptScore W2941492008C22744801 @default.
- W2941492008 hasConceptScore W2941492008C2777058267 @default.
- W2941492008 hasConceptScore W2941492008C2908647359 @default.
- W2941492008 hasConceptScore W2941492008C54355233 @default.
- W2941492008 hasConceptScore W2941492008C547475151 @default.
- W2941492008 hasConceptScore W2941492008C60987743 @default.
- W2941492008 hasConceptScore W2941492008C81977670 @default.
- W2941492008 hasConceptScore W2941492008C84597430 @default.
- W2941492008 hasConceptScore W2941492008C86803240 @default.
- W2941492008 hasConceptScore W2941492008C89423630 @default.
- W2941492008 hasConceptScore W2941492008C92938381 @default.
- W2941492008 hasIssue "1A" @default.
- W2941492008 hasLocation W29414920081 @default.
- W2941492008 hasOpenAccess W2941492008 @default.
- W2941492008 hasPrimaryLocation W29414920081 @default.
- W2941492008 hasRelatedWork W1826616185 @default.
- W2941492008 hasRelatedWork W2044392340 @default.
- W2941492008 hasRelatedWork W2092219958 @default.
- W2941492008 hasRelatedWork W2126017466 @default.
- W2941492008 hasRelatedWork W2346818983 @default.
- W2941492008 hasRelatedWork W2524850911 @default.
- W2941492008 hasRelatedWork W3005759147 @default.
- W2941492008 hasRelatedWork W3031886377 @default.
- W2941492008 hasRelatedWork W3215086467 @default.
- W2941492008 hasRelatedWork W4281612573 @default.
- W2941492008 hasVolume "1" @default.
- W2941492008 isParatext "false" @default.
- W2941492008 isRetracted "false" @default.
- W2941492008 magId "2941492008" @default.
- W2941492008 workType "article" @default.