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- W2941498877 abstract "Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months.Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation.Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups.Mismatch produces sexually dimorphic post-natal growth phenotypes." @default.
- W2941498877 created "2019-05-03" @default.
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- W2941498877 date "2019-04-26" @default.
- W2941498877 modified "2023-10-15" @default.
- W2941498877 title "Effect of maternal baboon ( <i>Papio</i> sp.) dietary mismatch in pregnancy and lactation on post‐natal offspring early life phenotype" @default.
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- W2941498877 doi "https://doi.org/10.1111/jmp.12415" @default.
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