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- W2941520608 abstract "Abstract Surface‐enhanced Raman spectroscopy (SERS) is a very powerful vibrational method that can be applied to a variety of biological samples provided that drawbacks, such as poor reproducibility of the signal and biocompatibility of the substrates, can be satisfactorily overcome. SERS is characterized by very low limits of detection, mainly due to the electromagnetic enhancement of the Raman signals, capable of achieving the single‐molecule level. Moreover, the spectra of small molecules represent authentic molecular fingerprints with very narrow linewidths that, along with the additional enhancement and inter‐/intramolecular selectivity gained through resonant laser excitation (surface‐enhanced resonance Raman spectroscopy, SERRS), make this technique particularly suited for multiplexing applications in complex biological samples. In this article, we introduce first the physical principles of SER(R)RS and describe the different types of substrates, as well as the basic modern instrumentation. We then provide an overview of recent biological applications, including biophysical mechanistic and structural studies on isolated biomolecules, their direct and indirect detection, chemical imaging of biological samples, and biomedical applications. Finally, we briefly discuss our outlook for the future research in this field." @default.
- W2941520608 created "2019-05-03" @default.
- W2941520608 creator A5037741742 @default.
- W2941520608 creator A5042563328 @default.
- W2941520608 date "2016-12-21" @default.
- W2941520608 modified "2023-10-09" @default.
- W2941520608 title "Surface‐Enhanced<scp>R</scp>aman Scattering of Biological Materials" @default.
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