FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941542022> ?p ?o ?g. }

• W2941542022 endingPage "670" @default.
• W2941542022 startingPage "659" @default.
• W2941542022 abstract "Background Chimeric antigen receptor (CAR)–T cell therapy opens a new era for cancer treatment. However, in prolonged follow-up, relapse has emerged as one of the major obstacles. Dendritic cell (DC) vaccination is a promising treatment to eradicate tumor cells and prevent relapse. The epidermal growth factor receptor (EGFR) pathway substrate 8 (Eps8) gene is involved in regulating cancer progression and is considered an attractive target for specific cancer immunotherapy. The purpose of this study was to explore a combinatorial therapy using CAR-T cells and a DC vaccine such as Eps8-DCs to increase leukemia treatment efficacy. Methods We pulsed DCs with Eps8-derived peptides to generate Eps8-DCs, engineered T cells to express a second-generation CAR specific for CD19, and analyzed the effects of the Eps8-DCs on the in vitro expansion, phenotype and effector functions of the CD19 CAR-T cells. Results The Eps8-DCs significantly reduced the activation-induced cell death and enhanced the proliferative potential of CAR-T cells during in vitro expansion. In addition, the expanded T cells co-cultured with the Eps8-DCs exhibited an increased percentage of central memory T cells (Tcms) and a decreased percentage of effector memory T cells (Tems). The Eps8-DCs enhanced CD19 CAR-T cell immune functions, including cytokine production, CD107a degranulation activity and cytotoxicity. Discussion This study demonstrates that Eps8-DCs exert synergistic effect on CD19 targeting CAR-T cells and paves the way for clinical trials using the combination of DC vaccination and engineered T cells in relapsed leukemia." @default.
• W2941542022 created "2019-05-03" @default.
• W2941542022 creator A5023708281 @default.
• W2941542022 creator A5029490013 @default.
• W2941542022 creator A5037091423 @default.
• W2941542022 creator A5056820617 @default.
• W2941542022 creator A5057180710 @default.
• W2941542022 creator A5071212122 @default.
• W2941542022 creator A5078010342 @default.
• W2941542022 date "2019-06-01" @default.
• W2941542022 modified "2023-10-09" @default.
• W2941542022 title "CD19 chimeric antigen receptor–redirected T cells combined with epidermal growth factor receptor pathway substrate 8 peptide–derived dendritic cell vaccine in leukemia" @default.
• W2941542022 cites W1967057211 @default.
• W2941542022 cites W1979829306 @default.
• W2941542022 cites W1982289474 @default.
• W2941542022 cites W1992450378 @default.
• W2941542022 cites W1993194658 @default.
• W2941542022 cites W1997383546 @default.
• W2941542022 cites W2035444344 @default.
• W2941542022 cites W2068302119 @default.
• W2941542022 cites W2068749976 @default.
• W2941542022 cites W2075030784 @default.
• W2941542022 cites W2089204070 @default.
• W2941542022 cites W2099570622 @default.
• W2941542022 cites W2099736081 @default.
• W2941542022 cites W2102439908 @default.
• W2941542022 cites W2113847305 @default.
• W2941542022 cites W2129702476 @default.
• W2941542022 cites W2135095550 @default.
• W2941542022 cites W2145738599 @default.
• W2941542022 cites W2155850103 @default.
• W2941542022 cites W2164301713 @default.
• W2941542022 cites W2219506342 @default.
• W2941542022 cites W2296829012 @default.
• W2941542022 cites W2342423058 @default.
• W2941542022 cites W2398243892 @default.
• W2941542022 cites W2463668308 @default.
• W2941542022 cites W2537448270 @default.
• W2941542022 cites W2556245106 @default.
• W2941542022 cites W2582357041 @default.
• W2941542022 cites W2586164131 @default.
• W2941542022 cites W2590810691 @default.
• W2941542022 cites W2592081641 @default.
• W2941542022 cites W2594967879 @default.
• W2941542022 cites W2596837612 @default.
• W2941542022 cites W2613659662 @default.
• W2941542022 cites W2653911491 @default.
• W2941542022 cites W2693970509 @default.
• W2941542022 cites W2748623468 @default.
• W2941542022 cites W2762987586 @default.
• W2941542022 cites W2763009861 @default.
• W2941542022 cites W2794413200 @default.
• W2941542022 cites W2794874600 @default.
• W2941542022 cites W2892007531 @default.
• W2941542022 cites W2892023224 @default.
• W2941542022 cites W2979789261 @default.
• W2941542022 doi "https://doi.org/10.1016/j.jcyt.2019.03.313" @default.
• W2941542022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31031152" @default.
• W2941542022 hasPublicationYear "2019" @default.
• W2941542022 type Work @default.
• W2941542022 sameAs 2941542022 @default.
• W2941542022 citedByCount "12" @default.
• W2941542022 countsByYear W29415420222020 @default.
• W2941542022 countsByYear W29415420222021 @default.
• W2941542022 countsByYear W29415420222022 @default.
• W2941542022 countsByYear W29415420222023 @default.
• W2941542022 crossrefType "journal-article" @default.
• W2941542022 hasAuthorship W2941542022A5023708281 @default.
• W2941542022 hasAuthorship W2941542022A5029490013 @default.
• W2941542022 hasAuthorship W2941542022A5037091423 @default.
• W2941542022 hasAuthorship W2941542022A5056820617 @default.
• W2941542022 hasAuthorship W2941542022A5057180710 @default.
• W2941542022 hasAuthorship W2941542022A5071212122 @default.
• W2941542022 hasAuthorship W2941542022A5078010342 @default.
• W2941542022 hasConcept C147483822 @default.
• W2941542022 hasConcept C154317977 @default.
• W2941542022 hasConcept C202751555 @default.
• W2941542022 hasConcept C203014093 @default.
• W2941542022 hasConcept C2776090121 @default.
• W2941542022 hasConcept C2777701055 @default.
• W2941542022 hasConcept C2778461978 @default.
• W2941542022 hasConcept C2778957590 @default.
• W2941542022 hasConcept C2780674031 @default.
• W2941542022 hasConcept C3875195 @default.
• W2941542022 hasConcept C502942594 @default.
• W2941542022 hasConcept C55493867 @default.
• W2941542022 hasConcept C86803240 @default.
• W2941542022 hasConcept C8891405 @default.
• W2941542022 hasConceptScore W2941542022C147483822 @default.
• W2941542022 hasConceptScore W2941542022C154317977 @default.
• W2941542022 hasConceptScore W2941542022C202751555 @default.
• W2941542022 hasConceptScore W2941542022C203014093 @default.
• W2941542022 hasConceptScore W2941542022C2776090121 @default.
• W2941542022 hasConceptScore W2941542022C2777701055 @default.
• W2941542022 hasConceptScore W2941542022C2778461978 @default.
• W2941542022 hasConceptScore W2941542022C2778957590 @default.
• W2941542022 hasConceptScore W2941542022C2780674031 @default.
• W2941542022 hasConceptScore W2941542022C3875195 @default.

• next