FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941569497> ?p ?o ?g. }

• W2941569497 abstract "Objectives The increased sensitivity of NGS for routine PGT-A has allowed the accurate classification of embryo biopsies as mosaic. Correspondingly, there is now a proportion of clinical cases in which there are no euploid embryos and at least one other mosaic for transfer consideration. This presents unique challenges to clinical decision makers about whether to transfer mosaic embryos. An increasing number of studies report normal live births after the transfer of mosaic embryos, but nonetheless, the issue of knowingly transferring an embryo with a detected abnormality is an ethically fraught issue. To the best of our knowledge however no studies have yet, in a sufficiently large cohort, audited the extent to which clinicians encounter this predicament and the extent to which it is related to maternal age. The objective of this study was therefore to address these two questions. Method Retrospective analysis of whole genome NGS PGT-A cases (Dec2015-Oct2017, Cooper Genomics). Re-biopsy, gender only and donor egg (age unknown) cases were excluded. Results 6,615 cases involving 27,396 biopsies were reviewed (table below) with the above categories in mind and in 4 age categories. The no euploid (1 or more mosaic) group constitutes 10.8% of the total and does not change significantly with maternal age. The one euploid (1 or more mosaic) group constitutes 10.1% of the total and reduces with maternal age, from 11.43% of cases associated with maternal age below 35, down to 6.10% of cases of patients over 40. Conclusions We found that 10-11% of cases only have a mosaic embryo available for transfer, and a further 10% of cases only have 1 euploid embryo and a further mosaic embryo available for double embryo transfer or a subsequent frozen embryo transfer. In these cases, clinical and genetic counselling involvement would be required to aid in decision making as to whether a mosaic embryo is to be transferred. Conversely, 80% of cases wouldn't present such a predicament with, 21% of cases only having aneuploid embryos reported and 59% of cases having one or more euploid embryos available (excl. our 1 euploid and 1 or more mosaic group). While the incidence of overall euploidy vs aneuploidy is clearly an age-related phenomenon on both an individual embryo and per case basis, the incidence of our two sub groups (each 10-11% of the total) does not appear to vary significantly with age with the possible exception of the “1 euploid and at least 1 mosaic” category in the over 40 age group. This suggests that the frequency of our two sub groups in question are more related to errors of mitosis (post-zygotic) than meiosis. It is important that we continue to monitor pregnancies and live birth outcomes where mosaic embryos are transferred to gather more information regarding those which are more likely to result in live births and low levels of pregnancy loss." @default.
• W2941569497 created "2019-05-03" @default.
• W2941569497 creator A5014139713 @default.
• W2941569497 creator A5044630886 @default.
• W2941569497 creator A5045568041 @default.
• W2941569497 creator A5060052931 @default.
• W2941569497 creator A5081518650 @default.
• W2941569497 date "2019-04-01" @default.
• W2941569497 modified "2023-09-23" @default.
• W2941569497 title "Mosaic embryos are not the only option for transfer in 90% of PGT-A cases" @default.
• W2941569497 doi "https://doi.org/10.1016/j.rbmo.2019.03.093" @default.
• W2941569497 hasPublicationYear "2019" @default.
• W2941569497 type Work @default.
• W2941569497 sameAs 2941569497 @default.
• W2941569497 citedByCount "0" @default.
• W2941569497 crossrefType "journal-article" @default.
• W2941569497 hasAuthorship W2941569497A5014139713 @default.
• W2941569497 hasAuthorship W2941569497A5044630886 @default.
• W2941569497 hasAuthorship W2941569497A5045568041 @default.
• W2941569497 hasAuthorship W2941569497A5060052931 @default.
• W2941569497 hasAuthorship W2941569497A5081518650 @default.
• W2941569497 hasConcept C104317684 @default.
• W2941569497 hasConcept C110739175 @default.
• W2941569497 hasConcept C118552586 @default.
• W2941569497 hasConcept C131872663 @default.
• W2941569497 hasConcept C142724271 @default.
• W2941569497 hasConcept C143191323 @default.
• W2941569497 hasConcept C160099875 @default.
• W2941569497 hasConcept C166957645 @default.
• W2941569497 hasConcept C167135981 @default.
• W2941569497 hasConcept C196843134 @default.
• W2941569497 hasConcept C2775934546 @default.
• W2941569497 hasConcept C2779234561 @default.
• W2941569497 hasConcept C50965678 @default.
• W2941569497 hasConcept C54355233 @default.
• W2941569497 hasConcept C71924100 @default.
• W2941569497 hasConcept C86803240 @default.
• W2941569497 hasConcept C95457728 @default.
• W2941569497 hasConceptScore W2941569497C104317684 @default.
• W2941569497 hasConceptScore W2941569497C110739175 @default.
• W2941569497 hasConceptScore W2941569497C118552586 @default.
• W2941569497 hasConceptScore W2941569497C131872663 @default.
• W2941569497 hasConceptScore W2941569497C142724271 @default.
• W2941569497 hasConceptScore W2941569497C143191323 @default.
• W2941569497 hasConceptScore W2941569497C160099875 @default.
• W2941569497 hasConceptScore W2941569497C166957645 @default.
• W2941569497 hasConceptScore W2941569497C167135981 @default.
• W2941569497 hasConceptScore W2941569497C196843134 @default.
• W2941569497 hasConceptScore W2941569497C2775934546 @default.
• W2941569497 hasConceptScore W2941569497C2779234561 @default.
• W2941569497 hasConceptScore W2941569497C50965678 @default.
• W2941569497 hasConceptScore W2941569497C54355233 @default.
• W2941569497 hasConceptScore W2941569497C71924100 @default.
• W2941569497 hasConceptScore W2941569497C86803240 @default.
• W2941569497 hasConceptScore W2941569497C95457728 @default.
• W2941569497 hasLocation W29415694971 @default.
• W2941569497 hasOpenAccess W2941569497 @default.
• W2941569497 hasPrimaryLocation W29415694971 @default.
• W2941569497 hasRelatedWork W1969171954 @default.
• W2941569497 hasRelatedWork W1975448251 @default.
• W2941569497 hasRelatedWork W2054552518 @default.
• W2941569497 hasRelatedWork W2056483233 @default.
• W2941569497 hasRelatedWork W2072937452 @default.
• W2941569497 hasRelatedWork W2073763067 @default.
• W2941569497 hasRelatedWork W2121202752 @default.
• W2941569497 hasRelatedWork W2151505578 @default.
• W2941569497 hasRelatedWork W2169476659 @default.
• W2941569497 hasRelatedWork W2183407559 @default.
• W2941569497 hasRelatedWork W2377651272 @default.
• W2941569497 hasRelatedWork W2409967510 @default.
• W2941569497 hasRelatedWork W2410726066 @default.
• W2941569497 hasRelatedWork W2424126263 @default.
• W2941569497 hasRelatedWork W2507854800 @default.
• W2941569497 hasRelatedWork W2522154325 @default.
• W2941569497 hasRelatedWork W2783374892 @default.
• W2941569497 hasRelatedWork W3011729098 @default.
• W2941569497 hasRelatedWork W3024608568 @default.
• W2941569497 hasRelatedWork W3025704491 @default.
• W2941569497 isParatext "false" @default.
• W2941569497 isRetracted "false" @default.
• W2941569497 magId "2941569497" @default.
• W2941569497 workType "article" @default.