Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941674263> ?p ?o ?g. }
- W2941674263 endingPage "1800143" @default.
- W2941674263 startingPage "1800143" @default.
- W2941674263 abstract "Protein-protein interactions within protein networks shape the human interactome, which often is promoted by specialized protein interaction modules, such as the postsynaptic density-95 (PSD-95), discs-large, zona occludens 1 (ZO-1) (PDZ) domains. PDZ domains play a role in several cellular functions, from cell-cell communication and polarization, to regulation of protein transport and protein metabolism. PDZ domain proteins are also crucial in the formation and stability of protein complexes, establishing an important bridge between extracellular stimuli detected by transmembrane receptors and intracellular responses. PDZ domains have been suggested as promising drug targets in several diseases, ranging from neurological and oncological disorders to viral infections. In this review, the authors describe structural and genetic aspects of PDZ-containing proteins and discuss the current status of the development of small-molecule and peptide modulators of PDZ domains. An overview of potential new therapeutic interventions in PDZ-mediated protein networks is also provided." @default.
- W2941674263 created "2019-05-03" @default.
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- W2941674263 creator A5082697577 @default.
- W2941674263 creator A5082781246 @default.
- W2941674263 creator A5091728466 @default.
- W2941674263 date "2019-04-24" @default.
- W2941674263 modified "2023-10-18" @default.
- W2941674263 title "PDZ Domains as Drug Targets" @default.
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