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• W2941765997 abstract "Objectives Otitis media with effusion (OME) is a common disease of childhood that is largely asymptomatic. However, middle ear fluid can persist for months and negatively impact a child's quality of life. Many cases of OME remain chronic and require surgical intervention. Because biofilms are known to contribute to the persistence of many diseases, this study examined effusions collected from children with chronic OME for the presence of essential biofilm structural components, members of the DNABII family of bacterial DNA‐binding proteins. Methods Middle ear effusions were recovered from 38 children with chronic OME at the time of tympanostomy tube insertion. A portion of each specimen was submitted for microbiology culture. The remaining material was assessed by immunoblot to quantitate individual DNABII proteins, integration host factor (IHF), and histone‐like protein (HU). Results Sixty‐five percent of effusions (24 of 37) were culture‐positive for bacterial species or yeast, whereas 35% (13 of 37) were culture‐negative. IHF was detected in 95% (36 of 38) at concentrations from 2 to 481 ng/μL effusion. HU was detected in 95% (36 of 38) and quantitated from 13 to 5,264 ng/μL effusion ( P ≤ 0.05 compared to IHF). Conclusion Because DNABII proteins are essential structural components of bacterial biofilms, these data lend further support to our understanding that biofilms are present in the vast majority of chronic middle ear effusions, despite negative culture results. The presence and ubiquity of DNABII proteins in OME specimens indicated that these proteins can serve as an important clinical target for our novel DNABII‐directed strategy to treat biofilm diseases such as chronic OME. Level of Evidence NA Laryngoscope , 130:806–811, 2020" @default.
• W2941765997 created "2019-05-03" @default.
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• W2941765997 date "2019-04-25" @default.
• W2941765997 modified "2023-10-06" @default.
• W2941765997 title "Identification of essential biofilm proteins in middle ear fluids of otitis media with effusion patients" @default.
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• W2941765997 doi "https://doi.org/10.1002/lary.28011" @default.
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