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- W2941775752 abstract "To establish successful infections, endoparasitoid wasps must develop strategies to evade immune responses of the host. Here, we identified and characterized a teratocytes-expressed gene encoding a trypsin inhibitor-like protein containing a cysteine-rich domain from Cotesia vestalis, CvT-TIL. CvT-TIL had a high expression level during the later developmental stage of teratocytes and was secreted into host hemolymph. Further experiments showed CvT-TIL strongly suppressed the prophenoloxidase activation of host hemolymph in a dose-dependent manner by interacting with PxPAP3 of PO cascade. Our results not only provide evidence for an inhibition between CvT-TIL gene and the host's melanization activity, but also expand our knowledge about the mechanisms by which parasitoids regulate humoral immunity of the host." @default.
- W2941775752 created "2019-05-03" @default.
- W2941775752 creator A5009542556 @default.
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- W2941775752 date "2019-07-01" @default.
- W2941775752 modified "2023-10-15" @default.
- W2941775752 title "A trypsin inhibitor-like protein secreted by Cotesia vestalis teratocytes inhibits hemolymph prophenoloxidase activation of Plutella xylostella" @default.
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- W2941775752 doi "https://doi.org/10.1016/j.jinsphys.2019.04.009" @default.
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