Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941791252> ?p ?o ?g. }
- W2941791252 endingPage "337" @default.
- W2941791252 startingPage "327" @default.
- W2941791252 abstract "Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a monogenetic inherited genodermatosis associated with deleterious mutations in the gene encoding type VII collagen (COL7A1). COL7A1 is essential for promoting attachment of the epidermis to the dermis, and its dysfunction may lead to generalized mucosal and cutaneous blistering associated to severe deformities. Currently, management of RDEB patients is limited to supportive care, being aimed at treating and preventing common complications associated with this condition. There is a great demand to develop targeted therapies for this devastating disease and RDEB research advances are currently being translated into clinical trials.Based on the literature and patent search, the authors have grouped the RDEB targeted therapies into five categories: a) cell-based therapies; b) gene therapy; c) protein replacement therapy; d) molecular therapy based on exon skipping; and e) drug-mediated premature termination codon read-through. The patent searching strategy involved inquiring Google and USPTO patent databases to reveal companies and institutions that are active in the area of RDEB targeted therapies.The patent landscape related to targeted therapies for RDEB is quite heterogeneous, with each targeted therapeutic approach being associated with its own challenges in achieving robust patent protection and identifying opportunities for future development." @default.
- W2941791252 created "2019-05-03" @default.
- W2941791252 creator A5011660309 @default.
- W2941791252 creator A5036266784 @default.
- W2941791252 creator A5065205606 @default.
- W2941791252 date "2019-04-24" @default.
- W2941791252 modified "2023-09-24" @default.
- W2941791252 title "Patent landscape of molecular and cellular targeted therapies for recessive dystrophic epidermolysis bullosa" @default.
- W2941791252 cites W1428940282 @default.
- W2941791252 cites W1518102216 @default.
- W2941791252 cites W1882758100 @default.
- W2941791252 cites W1969011049 @default.
- W2941791252 cites W1980562556 @default.
- W2941791252 cites W1989658917 @default.
- W2941791252 cites W1991274745 @default.
- W2941791252 cites W1994734184 @default.
- W2941791252 cites W2011479893 @default.
- W2941791252 cites W2016364090 @default.
- W2941791252 cites W2021449243 @default.
- W2941791252 cites W2023189220 @default.
- W2941791252 cites W2035272047 @default.
- W2941791252 cites W2038469788 @default.
- W2941791252 cites W2040578546 @default.
- W2941791252 cites W2046551884 @default.
- W2941791252 cites W2048704264 @default.
- W2941791252 cites W2048857735 @default.
- W2941791252 cites W2050870581 @default.
- W2941791252 cites W2052751433 @default.
- W2941791252 cites W2058726837 @default.
- W2941791252 cites W2060084652 @default.
- W2941791252 cites W2062078686 @default.
- W2941791252 cites W2064773694 @default.
- W2941791252 cites W2065114016 @default.
- W2941791252 cites W2065437076 @default.
- W2941791252 cites W2067756121 @default.
- W2941791252 cites W2069289373 @default.
- W2941791252 cites W2074343656 @default.
- W2941791252 cites W2074962579 @default.
- W2941791252 cites W2079025788 @default.
- W2941791252 cites W2085600205 @default.
- W2941791252 cites W2085811948 @default.
- W2941791252 cites W2087070256 @default.
- W2941791252 cites W2091249894 @default.
- W2941791252 cites W2094264280 @default.
- W2941791252 cites W2098214526 @default.
- W2941791252 cites W2099252894 @default.
- W2941791252 cites W2101879371 @default.
- W2941791252 cites W2115924787 @default.
- W2941791252 cites W2119151191 @default.
- W2941791252 cites W2134864266 @default.
- W2941791252 cites W2141779562 @default.
- W2941791252 cites W2158494985 @default.
- W2941791252 cites W2159638184 @default.
- W2941791252 cites W2160400422 @default.
- W2941791252 cites W2161162374 @default.
- W2941791252 cites W2167235468 @default.
- W2941791252 cites W2169459855 @default.
- W2941791252 cites W2217626770 @default.
- W2941791252 cites W2229527959 @default.
- W2941791252 cites W2292011078 @default.
- W2941791252 cites W2305792028 @default.
- W2941791252 cites W2323351229 @default.
- W2941791252 cites W2397641207 @default.
- W2941791252 cites W2415606543 @default.
- W2941791252 cites W2478595009 @default.
- W2941791252 cites W2484731858 @default.
- W2941791252 cites W2493097980 @default.
- W2941791252 cites W2534353326 @default.
- W2941791252 cites W2546735337 @default.
- W2941791252 cites W2580482078 @default.
- W2941791252 cites W2591192247 @default.
- W2941791252 cites W2619627699 @default.
- W2941791252 cites W2730585910 @default.
- W2941791252 cites W2735778907 @default.
- W2941791252 cites W2741065307 @default.
- W2941791252 cites W2774150879 @default.
- W2941791252 cites W2775153111 @default.
- W2941791252 cites W2787786437 @default.
- W2941791252 cites W2789879316 @default.
- W2941791252 cites W2799306261 @default.
- W2941791252 cites W2805375445 @default.
- W2941791252 cites W2884858329 @default.
- W2941791252 cites W2897705813 @default.
- W2941791252 cites W2897938509 @default.
- W2941791252 cites W3190095640 @default.
- W2941791252 cites W4248200597 @default.
- W2941791252 doi "https://doi.org/10.1080/13543776.2019.1608181" @default.
- W2941791252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31017019" @default.
- W2941791252 hasPublicationYear "2019" @default.
- W2941791252 type Work @default.
- W2941791252 sameAs 2941791252 @default.
- W2941791252 citedByCount "6" @default.
- W2941791252 countsByYear W29417912522019 @default.
- W2941791252 countsByYear W29417912522020 @default.
- W2941791252 countsByYear W29417912522021 @default.
- W2941791252 countsByYear W29417912522022 @default.
- W2941791252 crossrefType "journal-article" @default.
- W2941791252 hasAuthorship W2941791252A5011660309 @default.