FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941853033> ?p ?o ?g. }

• W2941853033 abstract "The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The NHE1 inhibitor cariporide has been demonstrated to inhibit human cancer cell lines. The goal of this study was to provide new sights into improved cancer cell chemosensitivity mediated by cariporide with activation of the apoptosis pathway.The NHE1 expression levels were first evaluated using the online database Oncomine and were determined by RT-PCR and western blot in vitro and in vivo. Cell proliferation was assessed In vitro through a CCK-8 assay, and apoptosis was analyzed by flow cytometry. An in vivo analysis was performed in BALB/c nude mice, which were intraperitoneally injected with MCF-7/ADR cells.NHE1 levels were significantly higher in breast cancer tissue than adjacent tissue, as well as in resistant cancer cells compared to sensitive cells. Cariporide induced the apoptosis of MCF-7/ADR cells and was associated with the intracellular accumulation of doxorubicin and G0/G1 cell cycle arrest. Moreover, cariporide decreased MDR1 expression and activated cleaved caspase-3 and caspase-9, promoting caspase-independent apoptosis in vitro. In vivo, cariporide significantly improved doxorubicin sensitivity in a xenograft model, enhancing tumor growth attenuation and diminishing tumor volume.Our results demonstrate that cariporide significantly facilitates the sensitivity of breast cancer to doxorubicin both in vitro and in vivo. This finding suggests that NHE1 may be a novel adjuvant therapeutic candidate for the treatment of resistant breast cancer." @default.
• W2941853033 created "2019-05-03" @default.
• W2941853033 creator A5014708668 @default.
• W2941853033 creator A5017559707 @default.
• W2941853033 creator A5020649070 @default.
• W2941853033 creator A5035548891 @default.
• W2941853033 creator A5074775577 @default.
• W2941853033 creator A5080704061 @default.
• W2941853033 date "2019-03-08" @default.
• W2941853033 modified "2023-09-25" @default.
• W2941853033 title "Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo" @default.
• W2941853033 cites W1515077778 @default.
• W2941853033 cites W1543790510 @default.
• W2941853033 cites W1780735337 @default.
• W2941853033 cites W1970469467 @default.
• W2941853033 cites W1975198903 @default.
• W2941853033 cites W1987323109 @default.
• W2941853033 cites W1989285620 @default.
• W2941853033 cites W1993262772 @default.
• W2941853033 cites W1994682335 @default.
• W2941853033 cites W2006434892 @default.
• W2941853033 cites W2023810324 @default.
• W2941853033 cites W2041115282 @default.
• W2941853033 cites W2044702943 @default.
• W2941853033 cites W2048054015 @default.
• W2941853033 cites W2051349300 @default.
• W2941853033 cites W2060315853 @default.
• W2941853033 cites W2064588823 @default.
• W2941853033 cites W2068050569 @default.
• W2941853033 cites W2070608798 @default.
• W2941853033 cites W2083205626 @default.
• W2941853033 cites W2093116529 @default.
• W2941853033 cites W2096283457 @default.
• W2941853033 cites W2096439168 @default.
• W2941853033 cites W2097347894 @default.
• W2941853033 cites W2099912042 @default.
• W2941853033 cites W2100826888 @default.
• W2941853033 cites W2109650103 @default.
• W2941853033 cites W2110132000 @default.
• W2941853033 cites W2114210952 @default.
• W2941853033 cites W2129408819 @default.
• W2941853033 cites W2136029031 @default.
• W2941853033 cites W2139198003 @default.
• W2941853033 cites W2152919759 @default.
• W2941853033 cites W2153303769 @default.
• W2941853033 cites W2153448114 @default.
• W2941853033 cites W2154453972 @default.
• W2941853033 cites W2157999078 @default.
• W2941853033 cites W2161954129 @default.
• W2941853033 cites W2163231723 @default.
• W2941853033 cites W2169351080 @default.
• W2941853033 cites W2171795919 @default.
• W2941853033 cites W2197144473 @default.
• W2941853033 cites W2272984102 @default.
• W2941853033 cites W2276617466 @default.
• W2941853033 cites W2292841174 @default.
• W2941853033 cites W2411750282 @default.
• W2941853033 cites W2415905463 @default.
• W2941853033 cites W2515702573 @default.
• W2941853033 cites W2546751622 @default.
• W2941853033 cites W2560367415 @default.
• W2941853033 cites W2570618306 @default.
• W2941853033 cites W2577235613 @default.
• W2941853033 cites W2588581252 @default.
• W2941853033 cites W2591682970 @default.
• W2941853033 cites W2745679292 @default.
• W2941853033 cites W2751809890 @default.
• W2941853033 cites W2767031674 @default.
• W2941853033 cites W2924800819 @default.
• W2941853033 cites W4247993601 @default.
• W2941853033 doi "https://doi.org/10.1186/s12885-019-5397-7" @default.
• W2941853033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6408845" @default.
• W2941853033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30849956" @default.
• W2941853033 hasPublicationYear "2019" @default.
• W2941853033 type Work @default.
• W2941853033 sameAs 2941853033 @default.
• W2941853033 citedByCount "36" @default.
• W2941853033 countsByYear W29418530332019 @default.
• W2941853033 countsByYear W29418530332020 @default.
• W2941853033 countsByYear W29418530332021 @default.
• W2941853033 countsByYear W29418530332022 @default.
• W2941853033 countsByYear W29418530332023 @default.
• W2941853033 crossrefType "journal-article" @default.
• W2941853033 hasAuthorship W2941853033A5014708668 @default.
• W2941853033 hasAuthorship W2941853033A5017559707 @default.
• W2941853033 hasAuthorship W2941853033A5020649070 @default.
• W2941853033 hasAuthorship W2941853033A5035548891 @default.
• W2941853033 hasAuthorship W2941853033A5074775577 @default.
• W2941853033 hasAuthorship W2941853033A5080704061 @default.
• W2941853033 hasBestOaLocation W29418530331 @default.
• W2941853033 hasConcept C121608353 @default.
• W2941853033 hasConcept C126322002 @default.
• W2941853033 hasConcept C150903083 @default.
• W2941853033 hasConcept C185592680 @default.
• W2941853033 hasConcept C190283241 @default.
• W2941853033 hasConcept C207001950 @default.
• W2941853033 hasConcept C2776694085 @default.
• W2941853033 hasConcept C2781303535 @default.
• W2941853033 hasConcept C502942594 @default.
• W2941853033 hasConcept C530470458 @default.

• next