FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941854566> ?p ?o ?g. }

• W2941854566 endingPage "69" @default.
• W2941854566 startingPage "64" @default.
• W2941854566 abstract "Background: Hepatitis C virus (HCV) related liver cirrhosis occurs in about 20% of chronically infected patients over a duration of 10–20 years, and within 5 years approximately 10–20% of these cirrhotic patients will develop hepatocellular carcinoma (HCC). Previous studies report that the X-ray repair cross-complementing group1 gene (XRCC1) is important in the risk of HCC development; however, results obtained from these studies are conflicting rather than conclusive. We hypothesised an association between single nucleotide polymorphisms (SNPs) in XRCC1 with the HCC risk on a background of chronic hepatitis C.Materials and methods: We recruited 210 subjects, 70 with HCC, 70 with cirrhosis and 70 healthy controls. Two SNPs [c.1254C>T(rs2293035) and c.1517G>C(rs139599857)] in XRCC1 were genotyped using created restriction site-polymerase chain reaction (CRS-PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) methods.Results: The TT genotype, CT genotype and T-allele in c.1254C>T (rs2293035) were linked to risk of HCC compared to the CC genotype: OR 3.58 [confidence interval (CI) 95%: 1.19–10.7] p = 0.019; OR 2.16 (CI 95%: 1.04–4.47) p = 0.037 and OR 2.10 (CI 95%: 1.2–3.3) p = 0.006, respectively. Regarding c.1517G>C (rs139599857), the CC genotype, GC genotype and C-allele were linked with higher risk of developing HCC compared to GG genotype: OR 4.77 (CI 95%: 1.3–16.9), p = 0.016; OR 3.02 (CI 95%: 1.46–6.2), p = 0.002 and OR 2.4 (CI 95%: 1.4–4.0), p = 0.001, respectively.Conclusion: We conclude that the T-allele of c.1254C>T (rs2293035) and the C allele of c.1517G>C (rs139599857) genetic variants may be associated with increased HCC risk among chronic hepatitis C patients." @default.
• W2941854566 created "2019-05-03" @default.
• W2941854566 creator A5019134452 @default.
• W2941854566 creator A5022158572 @default.
• W2941854566 creator A5030437392 @default.
• W2941854566 creator A5038513935 @default.
• W2941854566 creator A5072971208 @default.
• W2941854566 date "2019-04-03" @default.
• W2941854566 modified "2023-10-17" @default.
• W2941854566 title "Genetic variants of XRCC1 and risk of hepatocellular carcinoma in chronic hepatitis C patients" @default.
• W2941854566 cites W1619437178 @default.
• W2941854566 cites W1888784016 @default.
• W2941854566 cites W1966492619 @default.
• W2941854566 cites W1971517620 @default.
• W2941854566 cites W1975145355 @default.
• W2941854566 cites W1985059554 @default.
• W2941854566 cites W1985106074 @default.
• W2941854566 cites W1992261266 @default.
• W2941854566 cites W1994792621 @default.
• W2941854566 cites W1999928502 @default.
• W2941854566 cites W2012071848 @default.
• W2941854566 cites W2027199417 @default.
• W2941854566 cites W2028392042 @default.
• W2941854566 cites W2041037932 @default.
• W2941854566 cites W2043499239 @default.
• W2941854566 cites W2062903959 @default.
• W2941854566 cites W2067503117 @default.
• W2941854566 cites W2081201480 @default.
• W2941854566 cites W2083813165 @default.
• W2941854566 cites W2084339967 @default.
• W2941854566 cites W2099852042 @default.
• W2941854566 cites W2130877606 @default.
• W2941854566 cites W2165432409 @default.
• W2941854566 cites W2169002350 @default.
• W2941854566 cites W2169385554 @default.
• W2941854566 cites W2627335063 @default.
• W2941854566 cites W2808720392 @default.
• W2941854566 cites W2809833894 @default.
• W2941854566 cites W2889357555 @default.
• W2941854566 cites W2901865504 @default.
• W2941854566 cites W4245784696 @default.
• W2941854566 doi "https://doi.org/10.1080/09674845.2019.1594487" @default.
• W2941854566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31025604" @default.
• W2941854566 hasPublicationYear "2019" @default.
• W2941854566 type Work @default.
• W2941854566 sameAs 2941854566 @default.
• W2941854566 citedByCount "8" @default.
• W2941854566 countsByYear W29418545662019 @default.
• W2941854566 countsByYear W29418545662020 @default.
• W2941854566 countsByYear W29418545662021 @default.
• W2941854566 countsByYear W29418545662023 @default.
• W2941854566 crossrefType "journal-article" @default.
• W2941854566 hasAuthorship W2941854566A5019134452 @default.
• W2941854566 hasAuthorship W2941854566A5022158572 @default.
• W2941854566 hasAuthorship W2941854566A5030437392 @default.
• W2941854566 hasAuthorship W2941854566A5038513935 @default.
• W2941854566 hasAuthorship W2941854566A5072971208 @default.
• W2941854566 hasConcept C104317684 @default.
• W2941854566 hasConcept C126322002 @default.
• W2941854566 hasConcept C135763542 @default.
• W2941854566 hasConcept C153209595 @default.
• W2941854566 hasConcept C159047783 @default.
• W2941854566 hasConcept C168007829 @default.
• W2941854566 hasConcept C180754005 @default.
• W2941854566 hasConcept C2522874641 @default.
• W2941854566 hasConcept C2776408679 @default.
• W2941854566 hasConcept C2776999993 @default.
• W2941854566 hasConcept C2777214474 @default.
• W2941854566 hasConcept C2778019345 @default.
• W2941854566 hasConcept C54355233 @default.
• W2941854566 hasConcept C71924100 @default.
• W2941854566 hasConcept C86803240 @default.
• W2941854566 hasConcept C90924648 @default.
• W2941854566 hasConceptScore W2941854566C104317684 @default.
• W2941854566 hasConceptScore W2941854566C126322002 @default.
• W2941854566 hasConceptScore W2941854566C135763542 @default.
• W2941854566 hasConceptScore W2941854566C153209595 @default.
• W2941854566 hasConceptScore W2941854566C159047783 @default.
• W2941854566 hasConceptScore W2941854566C168007829 @default.
• W2941854566 hasConceptScore W2941854566C180754005 @default.
• W2941854566 hasConceptScore W2941854566C2522874641 @default.
• W2941854566 hasConceptScore W2941854566C2776408679 @default.
• W2941854566 hasConceptScore W2941854566C2776999993 @default.
• W2941854566 hasConceptScore W2941854566C2777214474 @default.
• W2941854566 hasConceptScore W2941854566C2778019345 @default.
• W2941854566 hasConceptScore W2941854566C54355233 @default.
• W2941854566 hasConceptScore W2941854566C71924100 @default.
• W2941854566 hasConceptScore W2941854566C86803240 @default.
• W2941854566 hasConceptScore W2941854566C90924648 @default.
• W2941854566 hasIssue "2" @default.
• W2941854566 hasLocation W29418545661 @default.
• W2941854566 hasLocation W29418545662 @default.
• W2941854566 hasOpenAccess W2941854566 @default.
• W2941854566 hasPrimaryLocation W29418545661 @default.
• W2941854566 hasRelatedWork W1974182763 @default.
• W2941854566 hasRelatedWork W1982541345 @default.
• W2941854566 hasRelatedWork W2008626862 @default.
• W2941854566 hasRelatedWork W2087123082 @default.

• next