Matches in SemOpenAlex for { <https://semopenalex.org/work/W2941910020> ?p ?o ?g. }
- W2941910020 endingPage "1619" @default.
- W2941910020 startingPage "1614" @default.
- W2941910020 abstract "Synthesized 3-benzyl(phenethyl)benzo[g]quinazolines (1–17) were evaluated in vitro to determine their effects against the anti-hepatitis A virus (HAV) using a cytopathic effect inhibition assay. Of the synthesized compounds, 16 and 17 showed considerably high anti-HAV activity, as indicated by their EC50 values of 27.59 and 18 μM, respectively, when compared to that of amantadine (37.3 μM), the standard therapeutic agent. In addition, they exhibited low cytotoxicity as indicated by their CC50 values, 290.63 and 569.45 μM, respectively. Compounds 1, 2, and 5 exhibited remarkable activity compared to the active compounds (16, 17) and amantadine. The selectivity index (SI) values were calculated and applied as a parameter for classifying the activity of the targets. In addition, molecular docking was performed to rationalize the SAR of the target compounds and analyze the binding modes between the docked-selected compounds and amino acid residues in the active site of the HAV-3C proteinase enzyme." @default.
- W2941910020 created "2019-05-03" @default.
- W2941910020 creator A5028013109 @default.
- W2941910020 creator A5041690609 @default.
- W2941910020 creator A5068299425 @default.
- W2941910020 creator A5075079154 @default.
- W2941910020 date "2019-07-01" @default.
- W2941910020 modified "2023-09-27" @default.
- W2941910020 title "Anti-HAV evaluation and molecular docking of newly synthesized 3-benzyl(phenethyl)benzo[g]quinazolines" @default.
- W2941910020 cites W1979542176 @default.
- W2941910020 cites W2008068385 @default.
- W2941910020 cites W2011267003 @default.
- W2941910020 cites W2014876088 @default.
- W2941910020 cites W2023371631 @default.
- W2941910020 cites W2030581388 @default.
- W2941910020 cites W2035047403 @default.
- W2941910020 cites W2045509933 @default.
- W2941910020 cites W2064531462 @default.
- W2941910020 cites W2064978957 @default.
- W2941910020 cites W2065263745 @default.
- W2941910020 cites W2067711789 @default.
- W2941910020 cites W2074261782 @default.
- W2941910020 cites W2080316118 @default.
- W2941910020 cites W2081033454 @default.
- W2941910020 cites W2092708753 @default.
- W2941910020 cites W2099366623 @default.
- W2941910020 cites W2105668062 @default.
- W2941910020 cites W2111799124 @default.
- W2941910020 cites W2114918609 @default.
- W2941910020 cites W2127661567 @default.
- W2941910020 cites W2128785009 @default.
- W2941910020 cites W2163359916 @default.
- W2941910020 cites W2178982287 @default.
- W2941910020 cites W2342199822 @default.
- W2941910020 cites W2490748781 @default.
- W2941910020 cites W2577423442 @default.
- W2941910020 cites W2733347532 @default.
- W2941910020 cites W2753469470 @default.
- W2941910020 cites W2756154600 @default.
- W2941910020 cites W2806121054 @default.
- W2941910020 cites W2807246168 @default.
- W2941910020 cites W2912378698 @default.
- W2941910020 cites W2950857566 @default.
- W2941910020 cites W4238011299 @default.
- W2941910020 doi "https://doi.org/10.1016/j.bmcl.2019.04.043" @default.
- W2941910020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31054861" @default.
- W2941910020 hasPublicationYear "2019" @default.
- W2941910020 type Work @default.
- W2941910020 sameAs 2941910020 @default.
- W2941910020 citedByCount "10" @default.
- W2941910020 countsByYear W29419100202020 @default.
- W2941910020 countsByYear W29419100202022 @default.
- W2941910020 countsByYear W29419100202023 @default.
- W2941910020 crossrefType "journal-article" @default.
- W2941910020 hasAuthorship W2941910020A5028013109 @default.
- W2941910020 hasAuthorship W2941910020A5041690609 @default.
- W2941910020 hasAuthorship W2941910020A5068299425 @default.
- W2941910020 hasAuthorship W2941910020A5075079154 @default.
- W2941910020 hasConcept C109316439 @default.
- W2941910020 hasConcept C118792377 @default.
- W2941910020 hasConcept C159110408 @default.
- W2941910020 hasConcept C161790260 @default.
- W2941910020 hasConcept C178910836 @default.
- W2941910020 hasConcept C181199279 @default.
- W2941910020 hasConcept C185592680 @default.
- W2941910020 hasConcept C202751555 @default.
- W2941910020 hasConcept C2775996393 @default.
- W2941910020 hasConcept C2777374534 @default.
- W2941910020 hasConcept C41183919 @default.
- W2941910020 hasConcept C41685203 @default.
- W2941910020 hasConcept C55493867 @default.
- W2941910020 hasConcept C71240020 @default.
- W2941910020 hasConcept C71924100 @default.
- W2941910020 hasConcept C96529984 @default.
- W2941910020 hasConcept C98274493 @default.
- W2941910020 hasConceptScore W2941910020C109316439 @default.
- W2941910020 hasConceptScore W2941910020C118792377 @default.
- W2941910020 hasConceptScore W2941910020C159110408 @default.
- W2941910020 hasConceptScore W2941910020C161790260 @default.
- W2941910020 hasConceptScore W2941910020C178910836 @default.
- W2941910020 hasConceptScore W2941910020C181199279 @default.
- W2941910020 hasConceptScore W2941910020C185592680 @default.
- W2941910020 hasConceptScore W2941910020C202751555 @default.
- W2941910020 hasConceptScore W2941910020C2775996393 @default.
- W2941910020 hasConceptScore W2941910020C2777374534 @default.
- W2941910020 hasConceptScore W2941910020C41183919 @default.
- W2941910020 hasConceptScore W2941910020C41685203 @default.
- W2941910020 hasConceptScore W2941910020C55493867 @default.
- W2941910020 hasConceptScore W2941910020C71240020 @default.
- W2941910020 hasConceptScore W2941910020C71924100 @default.
- W2941910020 hasConceptScore W2941910020C96529984 @default.
- W2941910020 hasConceptScore W2941910020C98274493 @default.
- W2941910020 hasFunder F4320335726 @default.
- W2941910020 hasIssue "13" @default.
- W2941910020 hasLocation W29419100201 @default.
- W2941910020 hasLocation W29419100202 @default.
- W2941910020 hasOpenAccess W2941910020 @default.
- W2941910020 hasPrimaryLocation W29419100201 @default.