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• W2941949392 abstract "ABSTRACT Lupeol, one of the common components from the fruits and natural foods, has been reported to exert antitumor activities in many human cancer cell lines; however, its effects on osteosarcoma cell metastasis were not elucidated. In the present study, lupeol at 10–25 μM induced cell morphological changes and decreased total viable cell number in U-2 OS cells. Lupeol (5–15 μM) suppressed cell mobility, migration, and invasion by wound healing and transwell chamber assays, respectively. Lupeol inhibited the activities of MMP-2 and −9 in U-2 OS cells by gelatin zymography assay. Lupeol significantly decreased PI3K, pAKT, β-catenin, and increased GSK3β. Furthermore, lupeol decreased the expressions of Ras, p-Raf-1, p-p38, and β-catenin. Lupeol also decreased uPA, MMP-2, MMP-9, and N-cadherin but increased VE-cadherin in U-2 OS cells. Based on these observations, we suggest that lupeol can be used in anti-metastasis of human osteosarcoma cells in the future." @default.
• W2941949392 created "2019-05-03" @default.
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• W2941949392 date "2019-09-02" @default.
• W2941949392 modified "2023-10-10" @default.
• W2941949392 title "Lupeol suppresses migration and invasion <i>via</i> p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells" @default.
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• W2941949392 doi "https://doi.org/10.1080/09168451.2019.1606693" @default.
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