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• W2941968892 abstract "Abstract Trichinella spiralis is a zoonotic nematode and food borne parasite and infection with T . spiralis leads to suppression of the host immune response and other immunopathologies. Alternative activated macrophages (M2) as well as T reg cells, a target for immunomodulation by the helminth parasite, play a critical role in initiating and modulating the host immune response to parasite. The precise mechanism by which helminths modulate host immune response is not fully understood. To determine the functions of parasite-induced M2 macrophages, we compared the effects of M1 and M2 macrophages obtained from Trichinella spiralis- infected mice with those of T . spiralis excretory/secretory (ES) protein-treated macrophages on experimental intestinal inflammation and allergic airway inflammation. T . spiralis infection induced M2 macrophage polarization by increasing the expression of CD206, ARG1 , and Fizz2 . In a single application, we introduced macrophages obtained from T . spiralis- infected mice and T . spiralis ES protein-treated macrophages into mice tail veins before the induction of dextran sulfate sodium (DSS)-induced colitis, ovalbumin (OVA)-alum sensitization, and OVA challenge. Colitis severity was assessed by determining the severity of colitis symptoms, colon length, histopathologic parameters, and Th1-related inflammatory cytokine levels. Compared with the DSS-colitis group, T . spiralis- infected mice and T . spiralis ES protein-treated macrophages showed significantly lower disease activity index (DAI) at sacrifice and smaller reductions of body weight and proinflammatory cytokine level. The severity of allergic airway inflammation was assessed by determining the severity of symptoms of inflammation, airway hyperresponsiveness (AHR), differential cell counts, histopathologic parameters, and levels of Th2-related inflammatory cytokines. Severe allergic airway inflammation was induced after OVA-alum sensitization and OVA challenge, which significantly increased Th2-related cytokine levels, eosinophil infiltration, and goblet cell hyperplasia in the lung. However, these severe allergic symptoms were significantly decreased in T. spiralis- infected mice and T. spiralis ES protein-treated macrophages. Helminth infection and helminth ES proteins induce M2 macrophages. Adoptive transfer of macrophages obtained from helminth-infected mice and helminth ES protein-activated macrophages is an effective treatment for preventing and treating airway allergy in mice and is promising as a therapeutic for treating inflammatory diseases." @default.
• W2941968892 created "2019-05-03" @default.
• W2941968892 creator A5000614964 @default.
• W2941968892 creator A5016789692 @default.
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• W2941968892 creator A5044335175 @default.
• W2941968892 creator A5048448756 @default.
• W2941968892 creator A5056146771 @default.
• W2941968892 creator A5056469803 @default.
• W2941968892 date "2019-04-25" @default.
• W2941968892 modified "2023-09-30" @default.
• W2941968892 title "Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models" @default.
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