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• W2941994549 abstract "You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma I (MP50)1 Apr 2019MP50-13 DEVELOPING A PREDICTION MODEL FOR DISEASE-FREE SURVIVAL FROM UPPER URINARY TRACT UROTHELIAL CARCINOMA IN THE KOREAN POPULATION: A RETROSPECTIVE MULTICENTER STUDY Sung Han Kim, Mi Kyung Song, Bumsik Hong, Seok Ho Kang, Byong Chang Jeong, Ja Hyeon Ku, and Ho Kyung Seo* Sung Han KimSung Han Kim More articles by this author , Mi Kyung SongMi Kyung Song More articles by this author , Bumsik HongBumsik Hong More articles by this author , Seok Ho KangSeok Ho Kang More articles by this author , Byong Chang JeongByong Chang Jeong More articles by this author , Ja Hyeon KuJa Hyeon Ku More articles by this author , and Ho Kyung Seo*Ho Kyung Seo* More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556413.16141.b0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: This study was aimed to propose a validated prediction model for disease-free survival (DFS) after radical nephroureterectomy (RNU) in a Korean population with upper urinary tract urothelial carcinoma (UTUC). METHODS: Retrospective review of 1561 cases of UTUC who underwent either open RNU (ONU, n = 906) or laparoscopic RNU (LNU, n = 615) from five tertiary Korean institutions between January 2000 and December 2012. Data were used to develop a prediction model using cox proportional hazards model. The prognostic factors were selected using the backward variable selection method. The prediction model performance was investigated by Harrell’s concordance index (C-index) and Hosmer-Lemeshow type two statistics. Internal validation was performed by bootstrap approach, and National Cancer Center data set (n = 128) was used for external validation. RESULTS: A best-fitting prediction model with seven significant factors was developed. The C-index and two Hosmer-Lemeshow type statistics of the prediction model were 0.785 (95% CI, 0.755-0.815), 4.810 (p = 0.8506), and 5.285 (p = 0.8088). The optimism-corrected estimate through the internal validation was 0.774 (95% CI, 0.744-0.804) and the optimism-corrected calibration curve was close to the ideal line with mean absolute error = 0.012. In external validation, the discrimination was 0.657 (95% CI, 0.560-0.755) and two calibration statistics were 0.790 (p = 0.9397) and 3.103 (p = 0.5408), respectively. CONCLUSIONS: A validated prediction model based on a large Korean RNU cohort was developed with acceptable performance to estimate DFS in patients with UTUC. Source of Funding: a Korean National Cancer Center grant (NCC1810242-1). Goyang, Korea, Republic of; seoul, Korea, Republic of; Goyang, Korea, Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e719-e720 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sung Han Kim More articles by this author Mi Kyung Song More articles by this author Bumsik Hong More articles by this author Seok Ho Kang More articles by this author Byong Chang Jeong More articles by this author Ja Hyeon Ku More articles by this author Ho Kyung Seo* More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2941994549 title "MP50-13 DEVELOPING A PREDICTION MODEL FOR DISEASE-FREE SURVIVAL FROM UPPER URINARY TRACT UROTHELIAL CARCINOMA IN THE KOREAN POPULATION: A RETROSPECTIVE MULTICENTER STUDY" @default.
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