Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942002013> ?p ?o ?g. }
- W2942002013 endingPage "2789" @default.
- W2942002013 startingPage "2774" @default.
- W2942002013 abstract "Kidney fibroblasts play a crucial role in dictating tubular cell fate and the outcome of acute kidney injury (AKI). The underlying mechanisms remain to be determined. Here, we found that mTOR signaling was activated in fibroblasts from mouse kidneys with ischemia/reperfusion injury (IRI). Ablation of fibroblast Rheb or Rictor promoted, while ablation of fibroblast Tsc1 protected against tubular cell death and IRI in mice. In tubular cells cultured with conditioned media (CM) from Rheb−/− or Rictor−/− fibroblasts, less hepatocyte growth factor (HGF) receptor c-met signaling activation or staurosporine-induced cell apoptosis was observed. While CM from Tsc1−/− fibroblasts promoted tubular cell c-met signaling activation and inhibited staurosporine-induced cell apoptosis. In kidney fibroblasts, blocking mTOR signaling downregulated the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and HGF. Downregulating fibroblast HGF expression or blocking tubular cell c-met signaling facilitated tubular cell apoptosis. Notably, renal PPARγ and HGF expression was less in mice with fibroblast Rheb or Rictor ablation, but more in mice with fibroblast Tsc1 ablation than their littermate controls, respectively. Together, these data suggest that mTOR signaling activation in kidney fibroblasts protects against tubular cell death and dictates the outcome of AKI through stimulating PPARγ and HGF expression." @default.
- W2942002013 created "2019-05-03" @default.
- W2942002013 creator A5017191784 @default.
- W2942002013 creator A5020480328 @default.
- W2942002013 creator A5035355183 @default.
- W2942002013 creator A5036591076 @default.
- W2942002013 creator A5037936921 @default.
- W2942002013 creator A5038779427 @default.
- W2942002013 creator A5041641534 @default.
- W2942002013 creator A5048270591 @default.
- W2942002013 creator A5052071384 @default.
- W2942002013 creator A5065772331 @default.
- W2942002013 creator A5065785367 @default.
- W2942002013 creator A5075512507 @default.
- W2942002013 creator A5091454967 @default.
- W2942002013 date "2019-04-25" @default.
- W2942002013 modified "2023-10-14" @default.
- W2942002013 title "Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury" @default.
- W2942002013 cites W1515372146 @default.
- W2942002013 cites W1874842075 @default.
- W2942002013 cites W1969881686 @default.
- W2942002013 cites W1971799714 @default.
- W2942002013 cites W1977352193 @default.
- W2942002013 cites W1983247384 @default.
- W2942002013 cites W1983350553 @default.
- W2942002013 cites W1986829962 @default.
- W2942002013 cites W2002639486 @default.
- W2942002013 cites W2010583480 @default.
- W2942002013 cites W2011282245 @default.
- W2942002013 cites W2013075901 @default.
- W2942002013 cites W2016518118 @default.
- W2942002013 cites W2018091219 @default.
- W2942002013 cites W2023853426 @default.
- W2942002013 cites W2029820289 @default.
- W2942002013 cites W2045892087 @default.
- W2942002013 cites W2047754866 @default.
- W2942002013 cites W2056123267 @default.
- W2942002013 cites W2065887259 @default.
- W2942002013 cites W2071441516 @default.
- W2942002013 cites W2073625832 @default.
- W2942002013 cites W2074628806 @default.
- W2942002013 cites W2074983969 @default.
- W2942002013 cites W2086974843 @default.
- W2942002013 cites W2088009584 @default.
- W2942002013 cites W2097804774 @default.
- W2942002013 cites W2101083009 @default.
- W2942002013 cites W2104207397 @default.
- W2942002013 cites W2109263914 @default.
- W2942002013 cites W2110470573 @default.
- W2942002013 cites W2113491029 @default.
- W2942002013 cites W2119940038 @default.
- W2942002013 cites W2129481102 @default.
- W2942002013 cites W2143421197 @default.
- W2942002013 cites W2147078969 @default.
- W2942002013 cites W2147501289 @default.
- W2942002013 cites W2150198473 @default.
- W2942002013 cites W2150433066 @default.
- W2942002013 cites W2159347821 @default.
- W2942002013 cites W2164965999 @default.
- W2942002013 cites W2170597525 @default.
- W2942002013 cites W2235325702 @default.
- W2942002013 cites W2257962987 @default.
- W2942002013 cites W2519386099 @default.
- W2942002013 cites W2559233139 @default.
- W2942002013 cites W2782417153 @default.
- W2942002013 cites W2783824513 @default.
- W2942002013 cites W2787402657 @default.
- W2942002013 cites W2901501609 @default.
- W2942002013 cites W265240098 @default.
- W2942002013 doi "https://doi.org/10.1038/s41418-019-0336-3" @default.
- W2942002013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7224397" @default.
- W2942002013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31024074" @default.
- W2942002013 hasPublicationYear "2019" @default.
- W2942002013 type Work @default.
- W2942002013 sameAs 2942002013 @default.
- W2942002013 citedByCount "24" @default.
- W2942002013 countsByYear W29420020132020 @default.
- W2942002013 countsByYear W29420020132021 @default.
- W2942002013 countsByYear W29420020132022 @default.
- W2942002013 countsByYear W29420020132023 @default.
- W2942002013 crossrefType "journal-article" @default.
- W2942002013 hasAuthorship W2942002013A5017191784 @default.
- W2942002013 hasAuthorship W2942002013A5020480328 @default.
- W2942002013 hasAuthorship W2942002013A5035355183 @default.
- W2942002013 hasAuthorship W2942002013A5036591076 @default.
- W2942002013 hasAuthorship W2942002013A5037936921 @default.
- W2942002013 hasAuthorship W2942002013A5038779427 @default.
- W2942002013 hasAuthorship W2942002013A5041641534 @default.
- W2942002013 hasAuthorship W2942002013A5048270591 @default.
- W2942002013 hasAuthorship W2942002013A5052071384 @default.
- W2942002013 hasAuthorship W2942002013A5065772331 @default.
- W2942002013 hasAuthorship W2942002013A5065785367 @default.
- W2942002013 hasAuthorship W2942002013A5075512507 @default.
- W2942002013 hasAuthorship W2942002013A5091454967 @default.
- W2942002013 hasBestOaLocation W29420020131 @default.
- W2942002013 hasConcept C126322002 @default.
- W2942002013 hasConcept C170493617 @default.
- W2942002013 hasConcept C185592680 @default.