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- W2942002137 abstract "The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth, metabolism, proliferation and survival. As a result, alterations in the PI3K pathway are frequently associated with human cancers. Indeed, PIK3CA—the gene encoding the p110α catalytic subunit of PI3K—is one of the most commonly mutated human oncogenes. PIK3CA mutations have also been implicated in non-malignant conditions including congenital overgrowth syndromes and vascular malformations. In order to study the role of PIK3CA mutations in driving tumorigenesis and tissue overgrowth and to test potential therapeutic interventions for these conditions, model systems are essential. In this review we discuss the various mouse models currently available for preclinical studies into the biological consequences and clinical significance of PIK3CA mutations." @default.
- W2942002137 created "2019-05-03" @default.
- W2942002137 creator A5025138822 @default.
- W2942002137 creator A5062132765 @default.
- W2942002137 date "2019-04-23" @default.
- W2942002137 modified "2023-09-23" @default.
- W2942002137 title "Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations" @default.
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- W2942002137 doi "https://doi.org/10.3390/biom9040158" @default.
- W2942002137 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6523081" @default.
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