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- W2942070912 abstract "The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the repositioning of genes and alteration of gene expression with oncogenic consequences. In this study, we analyzed the nuclear repositioning of HLXB9 (also called MNX1), mapping at 7q36.3, in patients with hematological disorders carrying interstitial deletions of 7q of various extents, with a distal breakpoint in 7q36. We observed that HLXB9 remains at the nuclear periphery, or is repositioned towards the nuclear interior, depending upon the compositional properties of the chromosomal regions involved in the rearrangement. For instance, a proximal breakpoint leading the guanine-cytosine (GC)-poor band 7q21 near 7q36 would bring HLXB9 to the nuclear periphery, whereas breakpoints that join the GC-rich band 7q22 to 7q36 would bring HLXB9 to the nuclear interior. This nuclear repositioning is associated with transcriptional changes, with HLXB9 in the nuclear interior becoming upregulated. Here we report an in cis rearrangement, involving one single chromosome altering gene behavior. Furthermore, we propose a mechanistic model for chromatin reorganization that affects gene expression via the influences of new chromatin neighborhoods." @default.
- W2942070912 created "2019-05-03" @default.
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- W2942070912 date "2019-04-25" @default.
- W2942070912 modified "2023-09-27" @default.
- W2942070912 title "Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders" @default.
- W2942070912 cites W1514779475 @default.
- W2942070912 cites W1546790153 @default.
- W2942070912 cites W1572616623 @default.
- W2942070912 cites W1577580034 @default.
- W2942070912 cites W1582394793 @default.
- W2942070912 cites W1593837562 @default.
- W2942070912 cites W1723358241 @default.
- W2942070912 cites W1887325245 @default.
- W2942070912 cites W191699600 @default.
- W2942070912 cites W1949649529 @default.
- W2942070912 cites W1954696475 @default.
- W2942070912 cites W1963188318 @default.
- W2942070912 cites W1970640134 @default.
- W2942070912 cites W1973062929 @default.
- W2942070912 cites W1977985048 @default.
- W2942070912 cites W1978700824 @default.
- W2942070912 cites W1979778637 @default.
- W2942070912 cites W1983170790 @default.
- W2942070912 cites W1986439120 @default.
- W2942070912 cites W1993982470 @default.
- W2942070912 cites W1995804693 @default.
- W2942070912 cites W2014703763 @default.
- W2942070912 cites W2023186182 @default.
- W2942070912 cites W2027694180 @default.
- W2942070912 cites W2038643289 @default.
- W2942070912 cites W2038657480 @default.
- W2942070912 cites W2038774969 @default.
- W2942070912 cites W2045291585 @default.
- W2942070912 cites W2049017075 @default.
- W2942070912 cites W2049612009 @default.
- W2942070912 cites W2061869519 @default.
- W2942070912 cites W2069905803 @default.
- W2942070912 cites W2070021921 @default.
- W2942070912 cites W2070509435 @default.
- W2942070912 cites W2079504701 @default.
- W2942070912 cites W2087973273 @default.
- W2942070912 cites W2090037139 @default.
- W2942070912 cites W2097637232 @default.
- W2942070912 cites W2098549100 @default.
- W2942070912 cites W2101845540 @default.
- W2942070912 cites W2112124900 @default.
- W2942070912 cites W2114715733 @default.
- W2942070912 cites W2116137577 @default.
- W2942070912 cites W2132090852 @default.
- W2942070912 cites W2135288330 @default.
- W2942070912 cites W2135416891 @default.
- W2942070912 cites W2137947368 @default.
- W2942070912 cites W2138046001 @default.
- W2942070912 cites W2138784587 @default.
- W2942070912 cites W2138784985 @default.
- W2942070912 cites W2143165983 @default.
- W2942070912 cites W2146427646 @default.
- W2942070912 cites W2148244829 @default.
- W2942070912 cites W2152152724 @default.
- W2942070912 cites W2153970111 @default.
- W2942070912 cites W2159435444 @default.
- W2942070912 cites W2159479483 @default.
- W2942070912 cites W2162967758 @default.
- W2942070912 cites W2170314963 @default.
- W2942070912 cites W2174420796 @default.
- W2942070912 cites W2185695501 @default.
- W2942070912 cites W2189671405 @default.
- W2942070912 cites W2209806217 @default.
- W2942070912 cites W2282923723 @default.
- W2942070912 cites W2284105410 @default.
- W2942070912 cites W2324665822 @default.
- W2942070912 cites W2396441324 @default.
- W2942070912 cites W2406071845 @default.
- W2942070912 cites W2418186850 @default.
- W2942070912 cites W2435330012 @default.
- W2942070912 cites W2512840607 @default.
- W2942070912 cites W2581280362 @default.
- W2942070912 cites W2607211817 @default.
- W2942070912 cites W2616198309 @default.
- W2942070912 cites W2734758234 @default.
- W2942070912 cites W2751017264 @default.
- W2942070912 cites W2756584474 @default.
- W2942070912 cites W2777060692 @default.