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- W2942118008 abstract "Background: Postmenopausal hormone treatment (HT) with estrogen alone (ET) or estrogen and progestin treatment (EPT) has been commonly used to alleviate menopausal symptoms. Treatments that contain 10 or more days of progestin per month have been considered relatively safe with respect to endometrial cancer risk. However, the endometrial safety of long-term use of EPT regimens is uncertain. Methods: We conducted a case-control study of 401 invasive endometrial cancer cases and 675 controls, nested within the California Teachers Study (CTS) cohort. We used unconditional multivariable logistic regression to obtain odds ratios (ORs) and 95% confidence intervals (CIs) for the association between long term use of hormone therapy and the risk of endometrial cancer and to examine the modifying effect of body mass index. Results: ET and sequential EPT treatments with less than 10 days of progestin per month were associated with a statistically significant elevated risk of endometrial cancer. Compared to HT never users, the ORs for 10 years or more use of these regimens were 4.4 (95% CI: 2.4 - 8.3) and 5.0 (95% CI: 1.9 - 13.4), respectively (both Ptrend Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4865." @default.
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- W2942118008 date "2009-05-01" @default.
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- W2942118008 title "Abstract #4865: Long-term postmenopausal hormone therapy and endometrial cancer" @default.
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