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• W2942170051 abstract "Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery. Specifically, SUMO-targeted ubiquitin ligases (STUbLs) have emerged as key players in nuclear quality control, genome maintenance, and transcription. However, how STUbLs select specific substrates among myriads of SUMOylated proteins on chromatin remains unclear. Here, we reveal a remarkable co-localization of the budding yeast STUbL Slx5/Slx8 and ubiquitin at seven genomic loci that we term ubiquitin hotspots. Ubiquitylation at these sites depends on Slx5/Slx8 and protein turnover on the Cdc48 segregase. We identify the transcription factor-like Ymr111c/Euc1 to associate with these sites and to be a critical determinant of ubiquitylation. Euc1 specifically targets Slx5/Slx8 to ubiquitin hotspots via bipartite binding of Slx5 that involves the Slx5 SUMO-interacting motifs and an additional, novel substrate recognition domain. Interestingly, the Euc1-ubiquitin hotspot pathway acts redundantly with chromatin modifiers of the H2A.Z and Rpd3L pathways in specific stress responses. Thus, our data suggest that STUbL-dependent ubiquitin hotspots shape chromatin during stress adaptation." @default.
• W2942170051 created "2019-05-03" @default.
• W2942170051 creator A5005419283 @default.
• W2942170051 creator A5026672805 @default.
• W2942170051 creator A5047771652 @default.
• W2942170051 creator A5065977507 @default.
• W2942170051 creator A5069736026 @default.
• W2942170051 creator A5070518024 @default.
• W2942170051 creator A5072746852 @default.
• W2942170051 date "2019-04-23" @default.
• W2942170051 modified "2023-10-18" @default.
• W2942170051 title "Slx5/Slx8‐dependent ubiquitin hotspots on chromatin contribute to stress tolerance" @default.
• W2942170051 cites W1490806999 @default.
• W2942170051 cites W1552907764 @default.
• W2942170051 cites W1689039642 @default.
• W2942170051 cites W1773018645 @default.
• W2942170051 cites W1784555856 @default.
• W2942170051 cites W1803102843 @default.
• W2942170051 cites W1956693522 @default.
• W2942170051 cites W1965818711 @default.
• W2942170051 cites W1977188840 @default.
• W2942170051 cites W1981835453 @default.
• W2942170051 cites W1984881591 @default.
• W2942170051 cites W1986888063 @default.
• W2942170051 cites W1989831269 @default.
• W2942170051 cites W1992131084 @default.
• W2942170051 cites W1994218254 @default.
• W2942170051 cites W1996611653 @default.
• W2942170051 cites W1998257113 @default.
• W2942170051 cites W1998838168 @default.
• W2942170051 cites W2013158844 @default.
• W2942170051 cites W2013289317 @default.
• W2942170051 cites W2019831987 @default.
• W2942170051 cites W2021618108 @default.
• W2942170051 cites W2028794261 @default.
• W2942170051 cites W2029189334 @default.
• W2942170051 cites W2036379364 @default.
• W2942170051 cites W2044287615 @default.
• W2942170051 cites W2045052763 @default.
• W2942170051 cites W2047350942 @default.
• W2942170051 cites W2047455709 @default.
• W2942170051 cites W2048966465 @default.
• W2942170051 cites W2067463001 @default.
• W2942170051 cites W2069258716 @default.
• W2942170051 cites W2071113403 @default.
• W2942170051 cites W2073946289 @default.
• W2942170051 cites W2084789302 @default.
• W2942170051 cites W2085196189 @default.
• W2942170051 cites W2087966689 @default.
• W2942170051 cites W2091602394 @default.
• W2942170051 cites W2095460783 @default.
• W2942170051 cites W2100200896 @default.
• W2942170051 cites W2105296700 @default.
• W2942170051 cites W2108228282 @default.
• W2942170051 cites W2109248504 @default.
• W2942170051 cites W2112746887 @default.
• W2942170051 cites W2114405956 @default.
• W2942170051 cites W2119126606 @default.
• W2942170051 cites W2119903882 @default.
• W2942170051 cites W2121441583 @default.
• W2942170051 cites W2122551230 @default.
• W2942170051 cites W2123070316 @default.
• W2942170051 cites W2128542570 @default.
• W2942170051 cites W2128926534 @default.
• W2942170051 cites W2133102806 @default.
• W2942170051 cites W2140373545 @default.
• W2942170051 cites W2141776370 @default.
• W2942170051 cites W2141955551 @default.
• W2942170051 cites W2143350753 @default.
• W2942170051 cites W2148469601 @default.
• W2942170051 cites W2149867107 @default.
• W2942170051 cites W2149993601 @default.
• W2942170051 cites W2152105724 @default.
• W2942170051 cites W2154823383 @default.
• W2942170051 cites W2157009395 @default.
• W2942170051 cites W2159100436 @default.
• W2942170051 cites W2168448928 @default.
• W2942170051 cites W2170372170 @default.
• W2942170051 cites W2181918089 @default.
• W2942170051 cites W2275585333 @default.
• W2942170051 cites W2284160770 @default.
• W2942170051 cites W2295030536 @default.
• W2942170051 cites W2323304212 @default.
• W2942170051 cites W2343526657 @default.
• W2942170051 cites W2345142877 @default.
• W2942170051 cites W2346640814 @default.
• W2942170051 cites W2490844245 @default.
• W2942170051 cites W2517678279 @default.
• W2942170051 cites W2521504251 @default.
• W2942170051 cites W2522417827 @default.
• W2942170051 cites W2559450437 @default.
• W2942170051 cites W2607931183 @default.
• W2942170051 cites W2612612834 @default.
• W2942170051 cites W2618329788 @default.
• W2942170051 cites W2626113720 @default.
• W2942170051 cites W2782360232 @default.
• W2942170051 cites W2916830745 @default.
• W2942170051 cites W4231297290 @default.
• W2942170051 cites W4233212869 @default.
• W2942170051 doi "https://doi.org/10.15252/embj.2018100368" @default.

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