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- W2942173609 abstract "Abstract Using mixed culture selection, we show how reduced envelope permeability, reduced target-site affinity, and increased β-lactamase production layer to confer aztreonam/β-lactamase inhibitor resistance in Escherichia coli. We report a clinical isolate producing CTX-M-15 and CMY-4, lacking OmpF, and carrying a PBP3 mutation. It is resistant to aztreonam plus the inhibitors avibactam, relebactam and vaborbactam. Mobilisation of bla SHV-12 into this isolate generated a derivative additionally resistant to aztreonam plus the bicyclic boronate inhibitors 2 and taniborbactam." @default.
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- W2942173609 date "2019-04-23" @default.
- W2942173609 modified "2023-09-23" @default.
- W2942173609 title "Resistance to aztreonam in combination with non-β-lactam β-lactamase inhibitors due to the layering of mechanisms in Escherichia coli identified following mixed culture selection" @default.
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- W2942173609 doi "https://doi.org/10.1101/615336" @default.
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