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- W2942175328 abstract "We thank Drs Ponzetto and Figura for their interest in our study entitled “Serological response to Helicobacter pylori proteins associate with risk of colorectal cancer among diverse populations in the United States.” We appreciate their comments on a potential causal relation between H pylori VacA protein and colorectal cancer development. Their hypothesis that VacA may increase the risk of colorectal cancer through a mechanism that is similar to that identified for cystic fibrosis could be of great importance to the question of how H pylori might contribute to colorectal carcinogenesis. We would like to point out, though, that we only indirectly and systemically assessed the presence of VacA through antibody responses against this protein in serum samples. Our data do not verify the presence of the bacterium nor the respective protein in colorectal cancer tissue. Further studies are needed to prove the presence of H pylori in the colon epithelium, as well as its potential direct effect. Assessing the presence of VacA and its potential to form chloride channels in host cells, as proposed by Drs Ponzetto and Figura, could thereby serve as a promising approach. Colon Cancer Risk and VacA Toxin of Helicobacter pyloriGastroenterologyVol. 156Issue 8PreviewButt et al1 observed an increased risk of developing colon rectal cancer in individuals possessing circulating antibodies to the vacuolating toxin (VacA) of Helicobacter pylori. Such a risk was particularly high for African Americans.1 Indeed, VacA forms chloride (Cl-) channels that become inserted into the cell and mitochondrial membranes,2 thereby reducing the membrane potential and mitochondrial energy production. The paradigm of altered Cl- handling is cystic fibrosis, and it is well-known that patients with this disease have a 5- to 10-fold increased risk of colon rectal cancer,3 as well of other gastrointestinal tract cancers,4 owing to the irregular activity of Cl- exchange by the cystic fibrosis transmembrane regulator. Full-Text PDF" @default.
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- W2942175328 date "2019-06-01" @default.
- W2942175328 modified "2023-09-25" @default.
- W2942175328 title "Reply" @default.
- W2942175328 doi "https://doi.org/10.1053/j.gastro.2019.04.040" @default.
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