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• W2942187859 startingPage "1618" @default.
• W2942187859 abstract "Employing a simple synthetic protocol, a series of highly effective halogen-substituted imidazole-thiosemicarbazides with anti-Toxoplasma gondii effects against the RH tachyzoites, much better than sulfadiazine, were obtained (IC50s 10.30—113.45 µg/mL vs. ~2721.45 µg/mL). The most potent of them, 12, 13, and 15, blocked the in vitro proliferation of T. gondii more potently than trimethoprim (IC50 12.13 µg/mL), as well. The results of lipophilicity studies collectively suggest that logP would be a rate-limiting factor for the anti-Toxoplasma activity of this class of compounds." @default.
• W2942187859 created "2019-05-03" @default.
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• W2942187859 date "2019-04-24" @default.
• W2942187859 modified "2023-10-16" @default.
• W2942187859 title "Discovery of Potent and Selective Halogen-Substituted Imidazole-Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro via Structure-Based Design" @default.
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• W2942187859 doi "https://doi.org/10.3390/molecules24081618" @default.
• W2942187859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6514996" @default.
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