FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942202823> ?p ?o ?g. }

• W2942202823 endingPage "1934578X1984270" @default.
• W2942202823 startingPage "1934578X1984270" @default.
• W2942202823 abstract "Polyalthic acid (PA) is a diterpene present in several trees of the Copaifera genus, with reported antitumor activity but poor water solubility. The aim of this work was the incorporation of PA in polymeric nanoparticles and the evaluation of the antiproliferative activity of this formulation in tumor (MCF-7) and normal (MCF-10A) breast cell lines. The nanoparticles were obtained by nanoprecipitation, using poly lactic-co-glycolic acid (PLGA) as the main material. Scanning electron microscopy showed nanoparticles with semispherical morphology, and dynamic light scattering measures revealed negative surface charge and average size of 98.64 ± 28 nm. The encapsulation efficiency was 98% and the drug loading was 15.6% ± 0.02%. Treatments with PA nanoparticles reduced cell proliferation more efficiently than free PA and the effect was selective on MCF-7 cells. Comet assay revealed a selective DNA damage induction by the nanoformulation on the tumor cells, which probably caused the antiproliferative effect. Our results show that PA incorporated in PLGA nanoparticles has potential as a selective cytostatic and genotoxic agent against MCF-7 cells." @default.
• W2942202823 created "2019-05-03" @default.
• W2942202823 creator A5010784964 @default.
• W2942202823 creator A5017953961 @default.
• W2942202823 creator A5024917425 @default.
• W2942202823 creator A5030601634 @default.
• W2942202823 creator A5039582010 @default.
• W2942202823 creator A5050202520 @default.
• W2942202823 creator A5072181454 @default.
• W2942202823 creator A5087418433 @default.
• W2942202823 date "2019-04-01" @default.
• W2942202823 modified "2023-09-27" @default.
• W2942202823 title "Polyalthic Acid in Polymeric Nanoparticles Causes Selective Growth Inhibition and Genotoxicity in MCF-7 Cells" @default.
• W2942202823 cites W1912849870 @default.
• W2942202823 cites W2037048276 @default.
• W2942202823 cites W2047824475 @default.
• W2942202823 cites W2054745605 @default.
• W2942202823 cites W2058542147 @default.
• W2942202823 cites W2078293698 @default.
• W2942202823 cites W2126902508 @default.
• W2942202823 cites W2129258621 @default.
• W2942202823 cites W2142279027 @default.
• W2942202823 cites W2144907950 @default.
• W2942202823 cites W2329049989 @default.
• W2942202823 cites W2391845610 @default.
• W2942202823 cites W2477620861 @default.
• W2942202823 cites W2575489306 @default.
• W2942202823 doi "https://doi.org/10.1177/1934578x19842702" @default.
• W2942202823 hasPublicationYear "2019" @default.
• W2942202823 type Work @default.
• W2942202823 sameAs 2942202823 @default.
• W2942202823 citedByCount "2" @default.
• W2942202823 countsByYear W29422028232020 @default.
• W2942202823 countsByYear W29422028232021 @default.
• W2942202823 crossrefType "journal-article" @default.
• W2942202823 hasAuthorship W2942202823A5010784964 @default.
• W2942202823 hasAuthorship W2942202823A5017953961 @default.
• W2942202823 hasAuthorship W2942202823A5024917425 @default.
• W2942202823 hasAuthorship W2942202823A5030601634 @default.
• W2942202823 hasAuthorship W2942202823A5039582010 @default.
• W2942202823 hasAuthorship W2942202823A5050202520 @default.
• W2942202823 hasAuthorship W2942202823A5072181454 @default.
• W2942202823 hasAuthorship W2942202823A5087418433 @default.
• W2942202823 hasBestOaLocation W29422028231 @default.
• W2942202823 hasConcept C109541995 @default.
• W2942202823 hasConcept C121608353 @default.
• W2942202823 hasConcept C12554922 @default.
• W2942202823 hasConcept C13965031 @default.
• W2942202823 hasConcept C143425029 @default.
• W2942202823 hasConcept C14631669 @default.
• W2942202823 hasConcept C155672457 @default.
• W2942202823 hasConcept C171250308 @default.
• W2942202823 hasConcept C178790620 @default.
• W2942202823 hasConcept C185592680 @default.
• W2942202823 hasConcept C192562407 @default.
• W2942202823 hasConcept C202751555 @default.
• W2942202823 hasConcept C2775920511 @default.
• W2942202823 hasConcept C2778959862 @default.
• W2942202823 hasConcept C2779707156 @default.
• W2942202823 hasConcept C2780165375 @default.
• W2942202823 hasConcept C2780358455 @default.
• W2942202823 hasConcept C2780472526 @default.
• W2942202823 hasConcept C29730261 @default.
• W2942202823 hasConcept C2994423619 @default.
• W2942202823 hasConcept C523546767 @default.
• W2942202823 hasConcept C54355233 @default.
• W2942202823 hasConcept C552990157 @default.
• W2942202823 hasConcept C55493867 @default.
• W2942202823 hasConcept C62112901 @default.
• W2942202823 hasConcept C86803240 @default.
• W2942202823 hasConcept C96232424 @default.
• W2942202823 hasConceptScore W2942202823C109541995 @default.
• W2942202823 hasConceptScore W2942202823C121608353 @default.
• W2942202823 hasConceptScore W2942202823C12554922 @default.
• W2942202823 hasConceptScore W2942202823C13965031 @default.
• W2942202823 hasConceptScore W2942202823C143425029 @default.
• W2942202823 hasConceptScore W2942202823C14631669 @default.
• W2942202823 hasConceptScore W2942202823C155672457 @default.
• W2942202823 hasConceptScore W2942202823C171250308 @default.
• W2942202823 hasConceptScore W2942202823C178790620 @default.
• W2942202823 hasConceptScore W2942202823C185592680 @default.
• W2942202823 hasConceptScore W2942202823C192562407 @default.
• W2942202823 hasConceptScore W2942202823C202751555 @default.
• W2942202823 hasConceptScore W2942202823C2775920511 @default.
• W2942202823 hasConceptScore W2942202823C2778959862 @default.
• W2942202823 hasConceptScore W2942202823C2779707156 @default.
• W2942202823 hasConceptScore W2942202823C2780165375 @default.
• W2942202823 hasConceptScore W2942202823C2780358455 @default.
• W2942202823 hasConceptScore W2942202823C2780472526 @default.
• W2942202823 hasConceptScore W2942202823C29730261 @default.
• W2942202823 hasConceptScore W2942202823C2994423619 @default.
• W2942202823 hasConceptScore W2942202823C523546767 @default.
• W2942202823 hasConceptScore W2942202823C54355233 @default.
• W2942202823 hasConceptScore W2942202823C552990157 @default.
• W2942202823 hasConceptScore W2942202823C55493867 @default.
• W2942202823 hasConceptScore W2942202823C62112901 @default.
• W2942202823 hasConceptScore W2942202823C86803240 @default.
• W2942202823 hasConceptScore W2942202823C96232424 @default.

• next