FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942223913> ?p ?o ?g. }

• W2942223913 abstract "You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II (MP41)1 Apr 2019MP41-10 SURVIVAL OUTCOMES OF INITIAL LOCAL THERAPY ON CLINICALLY LOCALIZED GLEASON 9-10 PROSTATE CANCER: A SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS DATABASE ANALYSIS Amy Nemirovsky*, Hubert Huang, Michael Naslund, and M. Minhaj Siddiqui Amy Nemirovsky*Amy Nemirovsky* More articles by this author , Hubert HuangHubert Huang More articles by this author , Michael NaslundMichael Naslund More articles by this author , and M. Minhaj SiddiquiM. Minhaj Siddiqui More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556193.07993.c2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Men with Gleason score 9-10 prostate cancer have significantly worse outcomes compared to those with Gleason score 8 disease. Choice of upfront treatments remain controversial for this patient cohort. Using the Surveillance, Epidemiology, and End Results (SEER) database, we evaluated the impact of initial treatment with external beam radiation therapy (EBRT), external beam radiation therapy with brachytherapy (EBRT+BT), or surgery on prostate cancer-specific mortality (PCSM) and overall mortality in Gleason 9-10 disease. METHODS: The SEER database was queried for men diagnosed with biopsy Gleason score 9-10 prostate cancer from 2004-2014. Only localized disease with clinical N0 and M0 status was included. Gathered data included demographic, pathologic, therapy received, and survival outcomes. Using JMP v11.0, Kaplan-Meier survival curves and univariate and multivariate analyses were generated for initial therapy with EBRT, EBRT+BT, or surgery. RESULTS: A total of 8,796 men were included with 4,988 (56.7%) who underwent upfront treatment with EBRT alone, 677 (7.7%) with EBRT+BT, and 3,131 (35.6%) with surgery. 7-year PCSM rates were 26.9%, 14.1%, and 13.7% for EBRT, EBRT+BT, and surgery respectively (p < 0.001)(figure 1). 7-year overall mortality rates were 41.6%, 26.3%, and 19.4% for EBRT, EBRT+BT, and surgery respectively (p < 0.001). When controlling for age, Gleason score, clinical T stage, and PSA level on multivariate analysis, EBRT had greater PCSM than either surgery or EBRT+BT (HR 0.36, 95% CI 0.25-0.51, p < 0.001 and HR 0.56, 95% CI 0.33-0.90, p = 0.015 respectively). Comparison of PCSM and overall mortality between surgery and EBRT+BT revealed HR 0.38 (95% CI 0.20-0.77, p = 0.01) and HR 0.49 (95% CI 0.33-0.76, p = 0.002) respectively. CONCLUSIONS: Among men with localized Gleason 9-10 disease, surgery and EBRT+BT showed significant improvement in survival outcomes compared to EBRT alone. When compared with EBRT+BT, surgery showed improvement in PCSM and overall mortality. Future prospective studies are warranted. Source of Funding: none Baltimore, MD© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e600-e600 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Amy Nemirovsky* More articles by this author Hubert Huang More articles by this author Michael Naslund More articles by this author M. Minhaj Siddiqui More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2942223913 created "2019-05-03" @default.
• W2942223913 creator A5006391173 @default.
• W2942223913 creator A5043343808 @default.
• W2942223913 creator A5051111179 @default.
• W2942223913 creator A5069427211 @default.
• W2942223913 date "2019-04-01" @default.
• W2942223913 modified "2023-09-23" @default.
• W2942223913 title "MP41-10 SURVIVAL OUTCOMES OF INITIAL LOCAL THERAPY ON CLINICALLY LOCALIZED GLEASON 9-10 PROSTATE CANCER: A SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS DATABASE ANALYSIS" @default.
• W2942223913 doi "https://doi.org/10.1097/01.ju.0000556193.07993.c2" @default.
• W2942223913 hasPublicationYear "2019" @default.
• W2942223913 type Work @default.
• W2942223913 sameAs 2942223913 @default.
• W2942223913 citedByCount "0" @default.
• W2942223913 crossrefType "journal-article" @default.
• W2942223913 hasAuthorship W2942223913A5006391173 @default.
• W2942223913 hasAuthorship W2942223913A5043343808 @default.
• W2942223913 hasAuthorship W2942223913A5051111179 @default.
• W2942223913 hasAuthorship W2942223913A5069427211 @default.
• W2942223913 hasBestOaLocation W29422239131 @default.
• W2942223913 hasConcept C107130276 @default.
• W2942223913 hasConcept C121608353 @default.
• W2942223913 hasConcept C126322002 @default.
• W2942223913 hasConcept C143998085 @default.
• W2942223913 hasConcept C2775908122 @default.
• W2942223913 hasConcept C2776235491 @default.
• W2942223913 hasConcept C2777416452 @default.
• W2942223913 hasConcept C2778162587 @default.
• W2942223913 hasConcept C2778527826 @default.
• W2942223913 hasConcept C2779391198 @default.
• W2942223913 hasConcept C2780192828 @default.
• W2942223913 hasConcept C29456083 @default.
• W2942223913 hasConcept C41008148 @default.
• W2942223913 hasConcept C509974204 @default.
• W2942223913 hasConcept C71924100 @default.
• W2942223913 hasConcept C72563966 @default.
• W2942223913 hasConcept C77088390 @default.
• W2942223913 hasConceptScore W2942223913C107130276 @default.
• W2942223913 hasConceptScore W2942223913C121608353 @default.
• W2942223913 hasConceptScore W2942223913C126322002 @default.
• W2942223913 hasConceptScore W2942223913C143998085 @default.
• W2942223913 hasConceptScore W2942223913C2775908122 @default.
• W2942223913 hasConceptScore W2942223913C2776235491 @default.
• W2942223913 hasConceptScore W2942223913C2777416452 @default.
• W2942223913 hasConceptScore W2942223913C2778162587 @default.
• W2942223913 hasConceptScore W2942223913C2778527826 @default.
• W2942223913 hasConceptScore W2942223913C2779391198 @default.
• W2942223913 hasConceptScore W2942223913C2780192828 @default.
• W2942223913 hasConceptScore W2942223913C29456083 @default.
• W2942223913 hasConceptScore W2942223913C41008148 @default.
• W2942223913 hasConceptScore W2942223913C509974204 @default.
• W2942223913 hasConceptScore W2942223913C71924100 @default.
• W2942223913 hasConceptScore W2942223913C72563966 @default.
• W2942223913 hasConceptScore W2942223913C77088390 @default.
• W2942223913 hasIssue "Supplement 4" @default.
• W2942223913 hasLocation W29422239131 @default.
• W2942223913 hasOpenAccess W2942223913 @default.
• W2942223913 hasPrimaryLocation W29422239131 @default.
• W2942223913 hasRelatedWork W1970337331 @default.
• W2942223913 hasRelatedWork W2051739660 @default.
• W2942223913 hasRelatedWork W2085529113 @default.
• W2942223913 hasRelatedWork W2093345003 @default.
• W2942223913 hasRelatedWork W2138863125 @default.
• W2942223913 hasRelatedWork W2185901097 @default.
• W2942223913 hasRelatedWork W2383175641 @default.
• W2942223913 hasRelatedWork W2597301728 @default.
• W2942223913 hasRelatedWork W2979210130 @default.
• W2942223913 hasRelatedWork W4243514755 @default.
• W2942223913 hasVolume "201" @default.
• W2942223913 isParatext "false" @default.
• W2942223913 isRetracted "false" @default.
• W2942223913 magId "2942223913" @default.
• W2942223913 workType "article" @default.