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- W2942253265 startingPage "596" @default.
- W2942253265 abstract "Ureaplasma diversum is a member of the Mollicutes class responsible for urogenital tract infection in cattle and small ruminants. Studies indicate that the process of horizontal gene transfer, the exchange of genetic material among different species, has a crucial role in mollicute evolution, affecting the group’s characteristic genomic reduction process and simplification of metabolic pathways. Using bioinformatics tools and the STRING database of known and predicted protein interactions, we constructed the protein–protein interaction network of U. diversum and compared it with the networks of other members of the Mollicutes class. We also investigated horizontal gene transfer events in subnetworks of interest involved in purine and pyrimidine metabolism and urease function, chosen because of their intrinsic importance for host colonization and virulence. We identified horizontal gene transfer events among Mollicutes and from Ureaplasma to Staphylococcus aureus and Corynebacterium, bacterial groups that colonize the urogenital niche. The overall tendency of genome reduction and simplification in the Mollicutes is echoed in their protein interaction networks, which tend to be more generalized and less selective. Our data suggest that the process was permitted (or enabled) by an increase in host dependence and the available gene repertoire in the urogenital tract shared via horizontal gene transfer." @default.
- W2942253265 created "2019-05-03" @default.
- W2942253265 creator A5031781033 @default.
- W2942253265 creator A5058776961 @default.
- W2942253265 creator A5088796122 @default.
- W2942253265 creator A5088816344 @default.
- W2942253265 date "2019-08-01" @default.
- W2942253265 modified "2023-10-12" @default.
- W2942253265 title "Ureaplasma diversumprotein interaction networks: evidence of horizontal gene transfer and evolution of reduced genomes amongMollicutes" @default.
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