Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942255040> ?p ?o ?g. }
- W2942255040 abstract "Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood. Here, we investigated the impact of constitutively inactivated 5-HT synthesis on context-dependent fear learning and extinction using tryptophan hydroxylase 2 (Tph2) knockout mice. Fear conditioning and context-dependent fear memory extinction paradigms were combined with c-Fos imaging and electrophysiological recordings in the dorsal hippocampus. Tph2 mutant mice, completely devoid of 5-HT synthesis in brain, displayed accelerated fear memory formation and increased locomotor responses to foot shock. Furthermore, recall of context-dependent fear memory and its extinction was increased. The behavioral responses were associated with increased c-Fos expression in the dorsal hippocampus and resistance to foot shock-induced impairment of hippocampal long-term potentiation (LTP). In conclusion, increased context-dependent fear memory resulting from brain 5-HT deficiency involves dysfunction of the hippocampal circuitry controlling contextual representation of fear-related behavioral responses." @default.
- W2942255040 created "2019-05-03" @default.
- W2942255040 creator A5009063031 @default.
- W2942255040 creator A5011360412 @default.
- W2942255040 creator A5014758020 @default.
- W2942255040 creator A5020963967 @default.
- W2942255040 creator A5023824836 @default.
- W2942255040 creator A5037449888 @default.
- W2942255040 creator A5038327791 @default.
- W2942255040 creator A5046922157 @default.
- W2942255040 creator A5063739360 @default.
- W2942255040 creator A5064712242 @default.
- W2942255040 creator A5066115513 @default.
- W2942255040 creator A5069738672 @default.
- W2942255040 creator A5071199052 @default.
- W2942255040 creator A5085762328 @default.
- W2942255040 creator A5089637604 @default.
- W2942255040 date "2019-04-24" @default.
- W2942255040 modified "2023-10-11" @default.
- W2942255040 title "Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity" @default.
- W2942255040 cites W1482114328 @default.
- W2942255040 cites W1525941959 @default.
- W2942255040 cites W1544607115 @default.
- W2942255040 cites W1592661589 @default.
- W2942255040 cites W1808441706 @default.
- W2942255040 cites W1967233463 @default.
- W2942255040 cites W1979715191 @default.
- W2942255040 cites W1986926390 @default.
- W2942255040 cites W1994918767 @default.
- W2942255040 cites W1997042372 @default.
- W2942255040 cites W1998712336 @default.
- W2942255040 cites W1998839982 @default.
- W2942255040 cites W1998899272 @default.
- W2942255040 cites W1999251867 @default.
- W2942255040 cites W2000987421 @default.
- W2942255040 cites W2003508747 @default.
- W2942255040 cites W2004886688 @default.
- W2942255040 cites W2006618461 @default.
- W2942255040 cites W2008083196 @default.
- W2942255040 cites W2016336988 @default.
- W2942255040 cites W2021113234 @default.
- W2942255040 cites W2025806474 @default.
- W2942255040 cites W2031543029 @default.
- W2942255040 cites W2032671919 @default.
- W2942255040 cites W2033103225 @default.
- W2942255040 cites W2037600975 @default.
- W2942255040 cites W2044524505 @default.
- W2942255040 cites W2046204510 @default.
- W2942255040 cites W2047033000 @default.
- W2942255040 cites W2048192788 @default.
- W2942255040 cites W2051005796 @default.
- W2942255040 cites W2052311880 @default.
- W2942255040 cites W2053081316 @default.
- W2942255040 cites W2054337546 @default.
- W2942255040 cites W2059956308 @default.
- W2942255040 cites W2060715005 @default.
- W2942255040 cites W2064063251 @default.
- W2942255040 cites W2064865856 @default.
- W2942255040 cites W2076246738 @default.
- W2942255040 cites W2083464770 @default.
- W2942255040 cites W2086544038 @default.
- W2942255040 cites W2105405311 @default.
- W2942255040 cites W2106095564 @default.
- W2942255040 cites W2111178305 @default.
- W2942255040 cites W2114773717 @default.
- W2942255040 cites W2116777802 @default.
- W2942255040 cites W2117763749 @default.
- W2942255040 cites W2118652709 @default.
- W2942255040 cites W2131618009 @default.
- W2942255040 cites W2137500715 @default.
- W2942255040 cites W2140201388 @default.
- W2942255040 cites W2155871949 @default.
- W2942255040 cites W2160278455 @default.
- W2942255040 cites W2167279371 @default.
- W2942255040 cites W2170684975 @default.
- W2942255040 cites W2171055927 @default.
- W2942255040 cites W2173903421 @default.
- W2942255040 cites W2273552927 @default.
- W2942255040 cites W2341471783 @default.
- W2942255040 cites W2415217866 @default.
- W2942255040 cites W2498411121 @default.
- W2942255040 cites W2565481281 @default.
- W2942255040 cites W2749538204 @default.
- W2942255040 cites W2764302607 @default.
- W2942255040 cites W2780908405 @default.
- W2942255040 cites W748214608 @default.
- W2942255040 doi "https://doi.org/10.3389/fnins.2019.00245" @default.
- W2942255040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6491456" @default.
- W2942255040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31068767" @default.
- W2942255040 hasPublicationYear "2019" @default.
- W2942255040 type Work @default.
- W2942255040 sameAs 2942255040 @default.
- W2942255040 citedByCount "23" @default.
- W2942255040 countsByYear W29422550402019 @default.
- W2942255040 countsByYear W29422550402020 @default.
- W2942255040 countsByYear W29422550402021 @default.
- W2942255040 countsByYear W29422550402022 @default.
- W2942255040 countsByYear W29422550402023 @default.
- W2942255040 crossrefType "journal-article" @default.
- W2942255040 hasAuthorship W2942255040A5009063031 @default.