Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942286871> ?p ?o ?g. }
- W2942286871 endingPage "10" @default.
- W2942286871 startingPage "1" @default.
- W2942286871 abstract "Rab26 GTPase modulates the trafficking of cell surface receptors, such as G protein-coupled receptors including α2-adrenergic receptors in some cell types. However, the effect of Rab26 on β2-adrenergic receptor (β2-AR) trafficking or/and Toll-like receptor 4 (TLR4) expression in human pulmonary microvascular endothelial cells (HPMECs) is still unclear. Here, we investigated the role of Rab26 in regulating the expression of β2-ARs and TLR4 in HPMECs and the effect of these receptors' imbalance on endothelial cell barrier function. The results showed that there was unbalance expression in these receptors, where β2-AR expression was remarkably reduced, and TLR4 was increased on the cell membrane after lipopolysaccharide (LPS) treatment. Furthermore, we found that Rab26 overexpression not only upregulated β2-ARs but also downregulated TLR4 expression on the cell membrane. Subsequently, the TLR4-related inflammatory response was greatly attenuated, and the hyperpermeability of HPMECs also was partially relived. Taken together, these data suggest that basal Rab26 maintains the balance between β2-ARs and TLR4 on the cell surface, and it might be a potential therapeutic target for diseases involving endothelial barrier dysfunction." @default.
- W2942286871 created "2019-05-03" @default.
- W2942286871 creator A5002797149 @default.
- W2942286871 creator A5004790499 @default.
- W2942286871 creator A5012992017 @default.
- W2942286871 creator A5020016656 @default.
- W2942286871 creator A5020022966 @default.
- W2942286871 creator A5026141417 @default.
- W2942286871 creator A5030618874 @default.
- W2942286871 creator A5040104068 @default.
- W2942286871 creator A5043135433 @default.
- W2942286871 creator A5045864407 @default.
- W2942286871 creator A5053320254 @default.
- W2942286871 creator A5066654480 @default.
- W2942286871 creator A5073261985 @default.
- W2942286871 creator A5085863346 @default.
- W2942286871 date "2019-04-28" @default.
- W2942286871 modified "2023-10-15" @default.
- W2942286871 title "Endothelial Cell Inflammation and Barriers Are Regulated by the Rab26-Mediated Balance between <i>β</i>2-AR and TLR4 in Pulmonary Microvessel Endothelial Cells" @default.
- W2942286871 cites W1496574098 @default.
- W2942286871 cites W1521920687 @default.
- W2942286871 cites W1967085548 @default.
- W2942286871 cites W1984089825 @default.
- W2942286871 cites W1988709385 @default.
- W2942286871 cites W1992923613 @default.
- W2942286871 cites W2016909149 @default.
- W2942286871 cites W2019245431 @default.
- W2942286871 cites W2043041195 @default.
- W2942286871 cites W2050986783 @default.
- W2942286871 cites W2071775013 @default.
- W2942286871 cites W2074860668 @default.
- W2942286871 cites W2083980656 @default.
- W2942286871 cites W2088220499 @default.
- W2942286871 cites W2099617023 @default.
- W2942286871 cites W2112001589 @default.
- W2942286871 cites W2114404607 @default.
- W2942286871 cites W2116682551 @default.
- W2942286871 cites W2121001808 @default.
- W2942286871 cites W2124274564 @default.
- W2942286871 cites W2125760444 @default.
- W2942286871 cites W2156566257 @default.
- W2942286871 cites W2160534582 @default.
- W2942286871 cites W2161150914 @default.
- W2942286871 cites W2171405356 @default.
- W2942286871 cites W2327150539 @default.
- W2942286871 cites W2507978151 @default.
- W2942286871 cites W2620241325 @default.
- W2942286871 cites W2735368216 @default.
- W2942286871 cites W2810154288 @default.
- W2942286871 cites W2887474745 @default.
- W2942286871 cites W2905771081 @default.
- W2942286871 cites W789594139 @default.
- W2942286871 doi "https://doi.org/10.1155/2019/7538071" @default.
- W2942286871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6512073" @default.
- W2942286871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31182932" @default.
- W2942286871 hasPublicationYear "2019" @default.
- W2942286871 type Work @default.
- W2942286871 sameAs 2942286871 @default.
- W2942286871 citedByCount "9" @default.
- W2942286871 countsByYear W29422868712019 @default.
- W2942286871 countsByYear W29422868712021 @default.
- W2942286871 countsByYear W29422868712022 @default.
- W2942286871 countsByYear W29422868712023 @default.
- W2942286871 crossrefType "journal-article" @default.
- W2942286871 hasAuthorship W2942286871A5002797149 @default.
- W2942286871 hasAuthorship W2942286871A5004790499 @default.
- W2942286871 hasAuthorship W2942286871A5012992017 @default.
- W2942286871 hasAuthorship W2942286871A5020016656 @default.
- W2942286871 hasAuthorship W2942286871A5020022966 @default.
- W2942286871 hasAuthorship W2942286871A5026141417 @default.
- W2942286871 hasAuthorship W2942286871A5030618874 @default.
- W2942286871 hasAuthorship W2942286871A5040104068 @default.
- W2942286871 hasAuthorship W2942286871A5043135433 @default.
- W2942286871 hasAuthorship W2942286871A5045864407 @default.
- W2942286871 hasAuthorship W2942286871A5053320254 @default.
- W2942286871 hasAuthorship W2942286871A5066654480 @default.
- W2942286871 hasAuthorship W2942286871A5073261985 @default.
- W2942286871 hasAuthorship W2942286871A5085863346 @default.
- W2942286871 hasBestOaLocation W29422868711 @default.
- W2942286871 hasConcept C104317684 @default.
- W2942286871 hasConcept C123012128 @default.
- W2942286871 hasConcept C127561419 @default.
- W2942286871 hasConcept C1491633281 @default.
- W2942286871 hasConcept C170493617 @default.
- W2942286871 hasConcept C202751555 @default.
- W2942286871 hasConcept C203014093 @default.
- W2942286871 hasConcept C2776070231 @default.
- W2942286871 hasConcept C2776914184 @default.
- W2942286871 hasConcept C2781236682 @default.
- W2942286871 hasConcept C502942594 @default.
- W2942286871 hasConcept C55493867 @default.
- W2942286871 hasConcept C62478195 @default.
- W2942286871 hasConcept C86803240 @default.
- W2942286871 hasConcept C95444343 @default.
- W2942286871 hasConceptScore W2942286871C104317684 @default.
- W2942286871 hasConceptScore W2942286871C123012128 @default.
- W2942286871 hasConceptScore W2942286871C127561419 @default.
- W2942286871 hasConceptScore W2942286871C1491633281 @default.