FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942346543> ?p ?o ?g. }

• W2942346543 abstract "How Salmonella enterica serovar Typhi (S. Typhi), an important human pathogen, survives the stressful microenvironments inside the gastrointestinal tract and within macrophages remains poorly understood. We report here that S. Typhi has a bonafide stringent response (SR) system, which is mediated by (p)ppGpp and regulates multiple virulence-associated traits and the pathogenicity of the S. Typhi Ty2 strain. In an iron overload mouse model of S. Typhi infection, the (p)ppGpp0 (Ty2ΔRelAΔSpoT) strain showed minimal systemic spread and no mortality, as opposed to 100% death of the mice challenged with the isogenic wild-type strain. Ty2ΔRelAΔSpoT had markedly elongated morphology with incomplete septa formation and demonstrated severely attenuated motility and chemotaxis due to the loss of flagella. Absence of the Vi-polysaccharide capsule rendered the mutant strain highly susceptible to complement-mediated lysis. The phenotypes of Ty2ΔRelAΔSpoT was contributed by transcriptional repression of several genes, including fliC, tviA, and ftsZ, as found by reverse transcriptase quantitative polymerase chain reaction and gene complementation studies. Finally, Ty2ΔRelAΔSpoT had markedly reduced invasion into intestinal epithelial cells and significantly attenuated survival within macrophages. To the best of our knowledge, this was the first study that addressed SR in S. Typhi and showed that (p)ppGpp was essential for optimal pathogenic fitness of the organism." @default.
• W2942346543 created "2019-05-03" @default.
• W2942346543 creator A5016333594 @default.
• W2942346543 creator A5029466870 @default.
• W2942346543 creator A5040627927 @default.
• W2942346543 creator A5074312780 @default.
• W2942346543 date "2019-05-09" @default.
• W2942346543 modified "2023-09-26" @default.
• W2942346543 title "Small alarmones (p)ppGpp regulate virulence associated traits and pathogenesis of<i>Salmonella enterica</i>serovar Typhi" @default.
• W2942346543 cites W1591558364 @default.
• W2942346543 cites W1616230851 @default.
• W2942346543 cites W1649550942 @default.
• W2942346543 cites W1688851527 @default.
• W2942346543 cites W1758928848 @default.
• W2942346543 cites W1773104009 @default.
• W2942346543 cites W1912958903 @default.
• W2942346543 cites W1964049648 @default.
• W2942346543 cites W1964979713 @default.
• W2942346543 cites W1969773207 @default.
• W2942346543 cites W1971507610 @default.
• W2942346543 cites W1973041435 @default.
• W2942346543 cites W1975853762 @default.
• W2942346543 cites W1982001714 @default.
• W2942346543 cites W1982679540 @default.
• W2942346543 cites W1987989007 @default.
• W2942346543 cites W1989074746 @default.
• W2942346543 cites W1989410164 @default.
• W2942346543 cites W1993955402 @default.
• W2942346543 cites W1999382865 @default.
• W2942346543 cites W2008186432 @default.
• W2942346543 cites W2008882394 @default.
• W2942346543 cites W2017016334 @default.
• W2942346543 cites W2019325003 @default.
• W2942346543 cites W2027526356 @default.
• W2942346543 cites W2034432345 @default.
• W2942346543 cites W2036158497 @default.
• W2942346543 cites W2037913221 @default.
• W2942346543 cites W2042048278 @default.
• W2942346543 cites W2059420748 @default.
• W2942346543 cites W2059869122 @default.
• W2942346543 cites W2063835272 @default.
• W2942346543 cites W2090390408 @default.
• W2942346543 cites W2097183117 @default.
• W2942346543 cites W2114213575 @default.
• W2942346543 cites W2116738290 @default.
• W2942346543 cites W2119820314 @default.
• W2942346543 cites W2121467305 @default.
• W2942346543 cites W2121915577 @default.
• W2942346543 cites W2123269578 @default.
• W2942346543 cites W2124008391 @default.
• W2942346543 cites W2124009524 @default.
• W2942346543 cites W2124392423 @default.
• W2942346543 cites W2124997977 @default.
• W2942346543 cites W2130527200 @default.
• W2942346543 cites W2138611595 @default.
• W2942346543 cites W2142788259 @default.
• W2942346543 cites W2143334851 @default.
• W2942346543 cites W2144942159 @default.
• W2942346543 cites W2147006435 @default.
• W2942346543 cites W2148111565 @default.
• W2942346543 cites W2159700448 @default.
• W2942346543 cites W2161756577 @default.
• W2942346543 cites W2167953261 @default.
• W2942346543 cites W2169660828 @default.
• W2942346543 cites W2170770817 @default.
• W2942346543 cites W2224856480 @default.
• W2942346543 cites W2275251131 @default.
• W2942346543 cites W2281180383 @default.
• W2942346543 cites W2338145181 @default.
• W2942346543 cites W2374393069 @default.
• W2942346543 cites W2395258196 @default.
• W2942346543 cites W2593353559 @default.
• W2942346543 cites W2700623028 @default.
• W2942346543 cites W81658165 @default.
• W2942346543 doi "https://doi.org/10.1111/cmi.13034" @default.
• W2942346543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31013389" @default.
• W2942346543 hasPublicationYear "2019" @default.
• W2942346543 type Work @default.
• W2942346543 sameAs 2942346543 @default.
• W2942346543 citedByCount "19" @default.
• W2942346543 countsByYear W29423465432019 @default.
• W2942346543 countsByYear W29423465432020 @default.
• W2942346543 countsByYear W29423465432021 @default.
• W2942346543 countsByYear W29423465432022 @default.
• W2942346543 countsByYear W29423465432023 @default.
• W2942346543 crossrefType "journal-article" @default.
• W2942346543 hasAuthorship W2942346543A5016333594 @default.
• W2942346543 hasAuthorship W2942346543A5029466870 @default.
• W2942346543 hasAuthorship W2942346543A5040627927 @default.
• W2942346543 hasAuthorship W2942346543A5074312780 @default.
• W2942346543 hasBestOaLocation W29423465431 @default.
• W2942346543 hasConcept C104317684 @default.
• W2942346543 hasConcept C127716648 @default.
• W2942346543 hasConcept C143065580 @default.
• W2942346543 hasConcept C159047783 @default.
• W2942346543 hasConcept C179069550 @default.
• W2942346543 hasConcept C2776460866 @default.
• W2942346543 hasConcept C2779607309 @default.
• W2942346543 hasConcept C2781065037 @default.
• W2942346543 hasConcept C2994552716 @default.

• next