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• W2942412015 abstract "Summary Chromosome association of the Chromosomal Passenger Complex (CPC; consisting of Borealin, Survivin, INCENP and the Aurora B kinase) is essential to achieve error-free chromosome segregation during cell division. Hence, understanding the mechanisms driving the chromosome association of the CPC is of paramount importance. Here using a multifaceted approach, we show that the CPC binds nucleosomes through a multivalent interaction predominantly involving Borealin. Strikingly, Survivin, previously suggested to target the CPC to centromeres [1–3] failed to bind nucleosomes on its own and requires Borealin and INCENP for its binding. Disrupting Borealin-nucleosome interactions excluded the CPC from chromosomes and caused chromosome congression defects. We also show that Borealin-mediated chromosome association of the CPC is critical for Haspin- and Bub1-mediated centromere enrichment of the CPC and works upstream of the latter. Our work thus establishes Borealin as a master regulator determining the chromosome association and function of the CPC." @default.
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• W2942412015 date "2019-04-26" @default.
• W2942412015 modified "2023-10-14" @default.
• W2942412015 title "Direct Nucleosome Binding of Borealin Secures Chromosome Association and Function of the Chromosomal Passenger complex" @default.
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• W2942412015 doi "https://doi.org/10.1101/620385" @default.
• W2942412015 hasPublicationYear "2019" @default.
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