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• W2942454265 endingPage "370" @default.
• W2942454265 startingPage "370" @default.
• W2942454265 abstract "Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in men. Currently, there is no effective treatment for castration-resistant prostate cancer (CRPC). There is, therefore, an urgent need to identify new therapeutic targets. The Hippo pathway and its downstream effectors—the transcriptional co-activators, Yes-associated protein (YAP) and its paralog, transcriptional co-activator with PDZ-binding motif (TAZ)—are foremost regulators of stem cells and cancer biology. Defective Hippo pathway signaling and YAP/TAZ hyperactivation are common across various cancers. Here, we draw on insights learned from other types of cancers and review the latest advances linking the Hippo pathway and YAP/TAZ to PCa onset and progression. We examine the regulatory interaction between Hippo-YAP/TAZ and the androgen receptor (AR), as main regulators of PCa development, and how uncontrolled expression of YAP/TAZ drives castration resistance by inducing cellular stemness. Finally, we survey the potential therapeutic targeting of the Hippo pathway and YAP/TAZ to overcome PCa." @default.
• W2942454265 created "2019-05-03" @default.
• W2942454265 creator A5067535356 @default.
• W2942454265 creator A5075113867 @default.
• W2942454265 date "2019-04-23" @default.
• W2942454265 modified "2023-10-02" @default.
• W2942454265 title "The Hippo Pathway in Prostate Cancer" @default.
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