Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942473559> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2942473559 endingPage "1579" @default.
- W2942473559 startingPage "1574" @default.
- W2942473559 abstract "Abstract In the present study, a small library of bisphenol Z ( BPZ ) derivatives was synthesized and investigated for anti‐proliferative effects in cultured breast and glioblastoma cell lines. Synthesized BPZ derivatives varied in molecular size, polarity, and lipophilicity. Of the 8 derivatives tested, compounds 4 and 6 , both of which displayed the highest degree of lipophilicity, were most active at inducing cell death as determined by the XTT assay. Cell membranes were interrogated using trypan blue staining and were shown to remain intact during treatments with 4 and 6 . Activation of caspase enzymes (3 and/or 7) was noted to occur following treatment with compound 4 . Polar BPZ derivatives, those with a substituted amine or alcohol, were devoid of any inhibitory or proliferative effects. The remaining derivatives seem to lack sufficient lipophilicity to execute an overt toxic effect. Our results suggest that increasing the lipophilic character of BPZ enhances the cytotoxic effects." @default.
- W2942473559 created "2019-05-03" @default.
- W2942473559 creator A5031785000 @default.
- W2942473559 creator A5046303821 @default.
- W2942473559 creator A5048574579 @default.
- W2942473559 creator A5050854245 @default.
- W2942473559 creator A5055364354 @default.
- W2942473559 creator A5060032204 @default.
- W2942473559 date "2019-05-16" @default.
- W2942473559 modified "2023-10-16" @default.
- W2942473559 title "Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives" @default.
- W2942473559 cites W1978497952 @default.
- W2942473559 cites W2003997116 @default.
- W2942473559 cites W2006104250 @default.
- W2942473559 cites W2026637605 @default.
- W2942473559 cites W2028945995 @default.
- W2942473559 cites W2031490538 @default.
- W2942473559 cites W2041101473 @default.
- W2942473559 cites W2042927035 @default.
- W2942473559 cites W2044528397 @default.
- W2942473559 cites W2045563337 @default.
- W2942473559 cites W2051826099 @default.
- W2942473559 cites W2078532276 @default.
- W2942473559 cites W2115891029 @default.
- W2942473559 cites W2118382645 @default.
- W2942473559 cites W2174355920 @default.
- W2942473559 cites W2586967350 @default.
- W2942473559 cites W2604852690 @default.
- W2942473559 cites W2950078685 @default.
- W2942473559 doi "https://doi.org/10.1111/cbdd.13531" @default.
- W2942473559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31009169" @default.
- W2942473559 hasPublicationYear "2019" @default.
- W2942473559 type Work @default.
- W2942473559 sameAs 2942473559 @default.
- W2942473559 citedByCount "2" @default.
- W2942473559 countsByYear W29424735592020 @default.
- W2942473559 countsByYear W29424735592023 @default.
- W2942473559 crossrefType "journal-article" @default.
- W2942473559 hasAuthorship W2942473559A5031785000 @default.
- W2942473559 hasAuthorship W2942473559A5046303821 @default.
- W2942473559 hasAuthorship W2942473559A5048574579 @default.
- W2942473559 hasAuthorship W2942473559A5050854245 @default.
- W2942473559 hasAuthorship W2942473559A5055364354 @default.
- W2942473559 hasAuthorship W2942473559A5060032204 @default.
- W2942473559 hasConcept C109316439 @default.
- W2942473559 hasConcept C131779359 @default.
- W2942473559 hasConcept C1491633281 @default.
- W2942473559 hasConcept C166595027 @default.
- W2942473559 hasConcept C178790620 @default.
- W2942473559 hasConcept C185592680 @default.
- W2942473559 hasConcept C201399114 @default.
- W2942473559 hasConcept C202751555 @default.
- W2942473559 hasConcept C21951064 @default.
- W2942473559 hasConcept C2779684741 @default.
- W2942473559 hasConcept C2780070996 @default.
- W2942473559 hasConcept C41625074 @default.
- W2942473559 hasConcept C55493867 @default.
- W2942473559 hasConcept C71240020 @default.
- W2942473559 hasConceptScore W2942473559C109316439 @default.
- W2942473559 hasConceptScore W2942473559C131779359 @default.
- W2942473559 hasConceptScore W2942473559C1491633281 @default.
- W2942473559 hasConceptScore W2942473559C166595027 @default.
- W2942473559 hasConceptScore W2942473559C178790620 @default.
- W2942473559 hasConceptScore W2942473559C185592680 @default.
- W2942473559 hasConceptScore W2942473559C201399114 @default.
- W2942473559 hasConceptScore W2942473559C202751555 @default.
- W2942473559 hasConceptScore W2942473559C21951064 @default.
- W2942473559 hasConceptScore W2942473559C2779684741 @default.
- W2942473559 hasConceptScore W2942473559C2780070996 @default.
- W2942473559 hasConceptScore W2942473559C41625074 @default.
- W2942473559 hasConceptScore W2942473559C55493867 @default.
- W2942473559 hasConceptScore W2942473559C71240020 @default.
- W2942473559 hasIssue "2" @default.
- W2942473559 hasLocation W29424735591 @default.
- W2942473559 hasLocation W29424735592 @default.
- W2942473559 hasOpenAccess W2942473559 @default.
- W2942473559 hasPrimaryLocation W29424735591 @default.
- W2942473559 hasRelatedWork W1964649030 @default.
- W2942473559 hasRelatedWork W1981832931 @default.
- W2942473559 hasRelatedWork W1987755785 @default.
- W2942473559 hasRelatedWork W1989198812 @default.
- W2942473559 hasRelatedWork W2053738763 @default.
- W2942473559 hasRelatedWork W2084246932 @default.
- W2942473559 hasRelatedWork W2165014838 @default.
- W2942473559 hasRelatedWork W2951614354 @default.
- W2942473559 hasRelatedWork W3027179485 @default.
- W2942473559 hasRelatedWork W3174433407 @default.
- W2942473559 hasVolume "94" @default.
- W2942473559 isParatext "false" @default.
- W2942473559 isRetracted "false" @default.
- W2942473559 magId "2942473559" @default.
- W2942473559 workType "article" @default.