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• W2942476711 abstract "Pain is a common nonmotor symptom of Parkinson's disease (PD) that remains neglected and misunderstood. Elucidating the nondopaminergic circuitry may be key to better understanding PD and improving current treatments. We investigated the role of monoamines in nociceptive behavior and descending analgesic circuitry in a rat 6-hydroxydopamine (6-OHDA)-induced PD model and explored the resulting motor dysfunctions and inflammatory responses. Rats pretreated with noradrenaline and serotonin reuptake inhibitors were given unilateral striatal 6-OHDA injections and evaluated for mechanical hyperalgesia and motor impairments. Through immunohistochemistry, the number and activation of neurons, and the staining for astrocytes, microglia and enkephalin were evaluated in specific brain structures and the dorsal horn of the spinal cord. The PD model induced bilateral mechanical hyperalgesia that was prevented by reuptake inhibitors in the paw contralateral to the lesion. Reuptake inhibitors also prevented postural immobility and asymmetric rotational behavior in PD rats without interfering with dopaminergic neuron loss or glial activation in the substantia nigra. However, the inhibitors changed the periaqueductal gray circuitry, protected against neuronal impairment in the locus coeruleus and nucleus raphe magnus, and normalized spinal enkephalin and glial staining in lesioned rats. These data indicate that the preservation of noradrenergic and serotonergic systems regulates motor responses and nociceptive circuitry during PD not by interfering directly with nigral lesions but by modulating the opioid system and glial response in the spinal cord. Taken together, these results suggest that nondopaminergic circuitry is essential to the motor and nonmotor symptoms of PD and must be further investigated." @default.
• W2942476711 created "2019-05-03" @default.
• W2942476711 creator A5007823349 @default.
• W2942476711 creator A5038308429 @default.
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• W2942476711 creator A5058359899 @default.
• W2942476711 creator A5085045805 @default.
• W2942476711 date "2019-08-01" @default.
• W2942476711 modified "2023-10-11" @default.
• W2942476711 title "Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model" @default.
• W2942476711 cites W150115087 @default.
• W2942476711 cites W1506736245 @default.
• W2942476711 cites W1520027060 @default.
• W2942476711 cites W1542901232 @default.
• W2942476711 cites W1553433790 @default.
• W2942476711 cites W1737973269 @default.
• W2942476711 cites W1907281603 @default.
• W2942476711 cites W1922248798 @default.
• W2942476711 cites W1964223116 @default.
• W2942476711 cites W1964600015 @default.
• W2942476711 cites W1965788826 @default.
• W2942476711 cites W1967720787 @default.
• W2942476711 cites W1968642035 @default.
• W2942476711 cites W1970083936 @default.
• W2942476711 cites W1976113746 @default.
• W2942476711 cites W1978776771 @default.
• W2942476711 cites W1979617003 @default.
• W2942476711 cites W1980452368 @default.
• W2942476711 cites W1982535961 @default.
• W2942476711 cites W1990487641 @default.
• W2942476711 cites W1999987381 @default.
• W2942476711 cites W2002287054 @default.
• W2942476711 cites W2003984170 @default.
• W2942476711 cites W2007635429 @default.
• W2942476711 cites W2008810019 @default.
• W2942476711 cites W2009182920 @default.
• W2942476711 cites W2011188338 @default.
• W2942476711 cites W2013164597 @default.
• W2942476711 cites W2021745579 @default.
• W2942476711 cites W2022942995 @default.
• W2942476711 cites W2024737755 @default.
• W2942476711 cites W2025885172 @default.
• W2942476711 cites W2029206809 @default.
• W2942476711 cites W2030330735 @default.
• W2942476711 cites W2035848101 @default.
• W2942476711 cites W2037155998 @default.
• W2942476711 cites W2038636807 @default.
• W2942476711 cites W2041272952 @default.
• W2942476711 cites W2042661317 @default.
• W2942476711 cites W2042884384 @default.
• W2942476711 cites W2049156701 @default.
• W2942476711 cites W2057679038 @default.
• W2942476711 cites W2058887324 @default.
• W2942476711 cites W2059084497 @default.
• W2942476711 cites W2060023105 @default.
• W2942476711 cites W2072621722 @default.
• W2942476711 cites W2072878237 @default.
• W2942476711 cites W2073449985 @default.
• W2942476711 cites W2076756254 @default.
• W2942476711 cites W2080855938 @default.
• W2942476711 cites W2080935562 @default.
• W2942476711 cites W2085813915 @default.
• W2942476711 cites W2086483799 @default.
• W2942476711 cites W2087350257 @default.
• W2942476711 cites W2087454739 @default.
• W2942476711 cites W2088300436 @default.
• W2942476711 cites W2088463141 @default.
• W2942476711 cites W2091061257 @default.
• W2942476711 cites W2094918547 @default.
• W2942476711 cites W2095317434 @default.
• W2942476711 cites W2097340392 @default.
• W2942476711 cites W2097447145 @default.
• W2942476711 cites W2103486522 @default.
• W2942476711 cites W2112174848 @default.
• W2942476711 cites W2116230226 @default.
• W2942476711 cites W2116954795 @default.
• W2942476711 cites W2120412340 @default.
• W2942476711 cites W2123037855 @default.
• W2942476711 cites W2138512124 @default.
• W2942476711 cites W2142389530 @default.
• W2942476711 cites W2155524482 @default.
• W2942476711 cites W2155964805 @default.
• W2942476711 cites W2156411508 @default.
• W2942476711 cites W2161722441 @default.
• W2942476711 cites W2166211493 @default.
• W2942476711 cites W2169890833 @default.
• W2942476711 cites W2170019750 @default.
• W2942476711 cites W2170809837 @default.
• W2942476711 cites W2266142923 @default.
• W2942476711 cites W2279564233 @default.
• W2942476711 cites W2322142561 @default.
• W2942476711 cites W2338136557 @default.
• W2942476711 cites W2339775526 @default.
• W2942476711 cites W2460352110 @default.
• W2942476711 cites W2523865002 @default.
• W2942476711 cites W2524405532 @default.
• W2942476711 cites W2583488971 @default.
• W2942476711 cites W2803143946 @default.

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