Matches in SemOpenAlex for { <https://semopenalex.org/work/W294248832> ?p ?o ?g. }
- W294248832 endingPage "276" @default.
- W294248832 startingPage "261" @default.
- W294248832 abstract "Common variable immunodeficiency (CVID) is a late-onset humoral deficiency characterized by B lymphocyte dysfunction or loss, decreased immunoglobulin production, and recurrent bacterial infections. CVID is the most frequent human primary immunodeficiency but still presents challenges in the understanding of its etiology and treatment. CVID in equine patients manifests with a natural impairment of B lymphocyte differentiation, and is a unique model to identify genetic and epigenetic mechanisms of disease. Bone marrow transcriptome analyses revealed decreased expression of genes indicative of the pro-B cell differentiation stage, importantly PAX5 (p≤0.023). We hypothesized that aberrant epigenetic regulation caused PAX5 gene silencing, resulting in the late-onset and non-familial manifestation of CVID. A significant increase in PAX5 enhancer region methylation was identified in equine CVID patients by genome-wide reduced-representation bisulfite sequencing and bisulfite PCR sequencing (p=0.000). Thus, we demonstrate that integrating transcriptomics and epigenetics in CVID enlightens potential mechanisms of dysfunctional B lymphopoiesis or function." @default.
- W294248832 created "2016-06-24" @default.
- W294248832 creator A5013030240 @default.
- W294248832 creator A5041221144 @default.
- W294248832 creator A5045894508 @default.
- W294248832 creator A5052991048 @default.
- W294248832 creator A5072111813 @default.
- W294248832 creator A5074421425 @default.
- W294248832 date "2015-10-01" @default.
- W294248832 modified "2023-10-14" @default.
- W294248832 title "Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation" @default.
- W294248832 cites W122007457 @default.
- W294248832 cites W1567059590 @default.
- W294248832 cites W1637403304 @default.
- W294248832 cites W1649308027 @default.
- W294248832 cites W1649547160 @default.
- W294248832 cites W1819491336 @default.
- W294248832 cites W1912537483 @default.
- W294248832 cites W1917059837 @default.
- W294248832 cites W1928772299 @default.
- W294248832 cites W1944128175 @default.
- W294248832 cites W1964730147 @default.
- W294248832 cites W1966384388 @default.
- W294248832 cites W1968561263 @default.
- W294248832 cites W1971677256 @default.
- W294248832 cites W1972191082 @default.
- W294248832 cites W1973065326 @default.
- W294248832 cites W1976133541 @default.
- W294248832 cites W1976393456 @default.
- W294248832 cites W1977123213 @default.
- W294248832 cites W1979568697 @default.
- W294248832 cites W1985537081 @default.
- W294248832 cites W1985578875 @default.
- W294248832 cites W1989305940 @default.
- W294248832 cites W1990630282 @default.
- W294248832 cites W1993648538 @default.
- W294248832 cites W1998065815 @default.
- W294248832 cites W1998167494 @default.
- W294248832 cites W1999047431 @default.
- W294248832 cites W2004104099 @default.
- W294248832 cites W2014263454 @default.
- W294248832 cites W2015930612 @default.
- W294248832 cites W2018427441 @default.
- W294248832 cites W2019206314 @default.
- W294248832 cites W2024090882 @default.
- W294248832 cites W2028616853 @default.
- W294248832 cites W2028784349 @default.
- W294248832 cites W2030203792 @default.
- W294248832 cites W2035419765 @default.
- W294248832 cites W2042063180 @default.
- W294248832 cites W2044724665 @default.
- W294248832 cites W2044993404 @default.
- W294248832 cites W2045721632 @default.
- W294248832 cites W2046464033 @default.
- W294248832 cites W2053155734 @default.
- W294248832 cites W2053734578 @default.
- W294248832 cites W2055413966 @default.
- W294248832 cites W2060081430 @default.
- W294248832 cites W2060383758 @default.
- W294248832 cites W2062618476 @default.
- W294248832 cites W2064302244 @default.
- W294248832 cites W2065293336 @default.
- W294248832 cites W2070745300 @default.
- W294248832 cites W2073379526 @default.
- W294248832 cites W2074880195 @default.
- W294248832 cites W2075453594 @default.
- W294248832 cites W2076477779 @default.
- W294248832 cites W2079687343 @default.
- W294248832 cites W2085625330 @default.
- W294248832 cites W2087549177 @default.
- W294248832 cites W2089478119 @default.
- W294248832 cites W2096916490 @default.
- W294248832 cites W2096999853 @default.
- W294248832 cites W2097065948 @default.
- W294248832 cites W2097851896 @default.
- W294248832 cites W2098027759 @default.
- W294248832 cites W2099673856 @default.
- W294248832 cites W2101545276 @default.
- W294248832 cites W2103121534 @default.
- W294248832 cites W2105191357 @default.
- W294248832 cites W2105766695 @default.
- W294248832 cites W2110883977 @default.
- W294248832 cites W2114104545 @default.
- W294248832 cites W2114270276 @default.
- W294248832 cites W2116909043 @default.
- W294248832 cites W2124369311 @default.
- W294248832 cites W2125310129 @default.
- W294248832 cites W2126463975 @default.
- W294248832 cites W2126766896 @default.
- W294248832 cites W2128880918 @default.
- W294248832 cites W2130202009 @default.
- W294248832 cites W2130651020 @default.
- W294248832 cites W2131060369 @default.
- W294248832 cites W2131374955 @default.
- W294248832 cites W2133465414 @default.
- W294248832 cites W2136846143 @default.
- W294248832 cites W2137462480 @default.
- W294248832 cites W2139122477 @default.