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- W2942533991 abstract "Polydimethylsiloxane (PDMS)-based elastomers have become the de facto platform for various biomedical applications. But the stable attachment of biomolecules to PDMS for more robust and long-term performance of the PDMS-based devices has been a significant challenge, owing to its unique physical properties (e.g. hydrophobicity, dynamic molecular mobility). Herein, the PDMS membrane with tunable surface porosity is developed via high-pressure saturated steam technology in order to promote a strong and lasting bioadhesion to the PDMS membrane without additional processing steps. The resulting porous PDMS membranes demonstrate enhanced physical properties (e.g. Young's modulus, roughness, and air permeability), which is dependent on the membrane thickness. The bioactivity of porous PDMS membranes, evaluated by measuring the adhesion of various biomolecules and bioactivity of cells, shows significant improvement over conventional non-porous control. This effect can be attributed to the strong physical adsorption on the porous PDMS membrane by increased surface roughness and stiffness. In sum, the porous PDMS membrane provides a simple and yet highly effective platform to create bioactive surface for various biomedical devices." @default.
- W2942533991 created "2019-05-09" @default.
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- W2942533991 date "2019-05-31" @default.
- W2942533991 modified "2023-09-30" @default.
- W2942533991 title "Comprehensive tuning of bioadhesive properties of polydimethylsiloxane (PDMS) membranes with controlled porosity" @default.
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- W2942533991 doi "https://doi.org/10.1088/1758-5090/ab1da9" @default.
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