FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942550960> ?p ?o ?g. }

• W2942550960 endingPage "21134" @default.
• W2942550960 startingPage "21126" @default.
• W2942550960 abstract "c-Myb regulates tumorigenesis in multiple cancers. Here we show, for the first time, the mechanism of c-Myb-mediated proliferation, invasion, and drug resistance in ovarian cancer (OC), the most lethal gynecological cancer, and a comparative analyses of dietary agents, curcumin, epigallocatechin-3-gallate (EGCG), and sulforaphane in inhibiting c-Myb activity. We evaluated myb expression in patients with OC and found its increased expression in patients with cancer, compared with normal controls and in higher grade tumors, compared with low-grade tumors. Using ES2 and OVCAR3 cell line models, along with the silencing or overexpression of c-Myb, we establish a role of c-Myb in determining resistance to cisplatin. c-Myb overexpression activated NF-κB and STAT3 signaling leading to enhanced proliferation, invasion, and cisplatin resistance. Contrary to this, silencing of c-Myb inhibited proliferation, invasion, and sensitized OC cells to cisplatin. Further, among the dietary agents tested, EGCG almost completely inhibited the c-Myb-induced proliferation and invasion whereas sulforaphane also had significant inhibitory effect. Both compounds significantly sensitized OC cells to cisplatin, reversing the c-Myb effects. Higher c-Myb levels in patients with ovarian cancer lead to poor survival and our results indicate a possible effect of dietary factors EGCG and sulforaphane against c-Myb-mediated ovarian cancer progression and chemoresistance." @default.
• W2942550960 created "2019-05-09" @default.
• W2942550960 creator A5045108588 @default.
• W2942550960 creator A5071866732 @default.
• W2942550960 creator A5083283473 @default.
• W2942550960 creator A5083602758 @default.
• W2942550960 creator A5086155499 @default.
• W2942550960 date "2019-04-29" @default.
• W2942550960 modified "2023-10-14" @default.
• W2942550960 title "Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors" @default.
• W2942550960 cites W1942602300 @default.
• W2942550960 cites W2020636600 @default.
• W2942550960 cites W2030191482 @default.
• W2942550960 cites W2066661956 @default.
• W2942550960 cites W2071312597 @default.
• W2942550960 cites W2086720243 @default.
• W2942550960 cites W2239148419 @default.
• W2942550960 cites W2277854123 @default.
• W2942550960 cites W2341820907 @default.
• W2942550960 cites W2423990716 @default.
• W2942550960 cites W2468995898 @default.
• W2942550960 cites W2473595707 @default.
• W2942550960 cites W2483781252 @default.
• W2942550960 cites W2537497520 @default.
• W2942550960 cites W2546830379 @default.
• W2942550960 cites W2737049961 @default.
• W2942550960 cites W2745155203 @default.
• W2942550960 cites W2761627563 @default.
• W2942550960 cites W2765210128 @default.
• W2942550960 cites W2766082421 @default.
• W2942550960 cites W2766219330 @default.
• W2942550960 cites W2800036023 @default.
• W2942550960 cites W2887746262 @default.
• W2942550960 cites W2889164950 @default.
• W2942550960 cites W2890246395 @default.
• W2942550960 cites W4200120136 @default.
• W2942550960 cites W2794170944 @default.
• W2942550960 doi "https://doi.org/10.1002/jcp.28715" @default.
• W2942550960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31037726" @default.
• W2942550960 hasPublicationYear "2019" @default.
• W2942550960 type Work @default.
• W2942550960 sameAs 2942550960 @default.
• W2942550960 citedByCount "44" @default.
• W2942550960 countsByYear W29425509602019 @default.
• W2942550960 countsByYear W29425509602020 @default.
• W2942550960 countsByYear W29425509602021 @default.
• W2942550960 countsByYear W29425509602022 @default.
• W2942550960 countsByYear W29425509602023 @default.
• W2942550960 crossrefType "journal-article" @default.
• W2942550960 hasAuthorship W2942550960A5045108588 @default.
• W2942550960 hasAuthorship W2942550960A5071866732 @default.
• W2942550960 hasAuthorship W2942550960A5083283473 @default.
• W2942550960 hasAuthorship W2942550960A5083602758 @default.
• W2942550960 hasAuthorship W2942550960A5086155499 @default.
• W2942550960 hasConcept C104317684 @default.
• W2942550960 hasConcept C121332964 @default.
• W2942550960 hasConcept C121608353 @default.
• W2942550960 hasConcept C123079801 @default.
• W2942550960 hasConcept C126322002 @default.
• W2942550960 hasConcept C143998085 @default.
• W2942550960 hasConcept C185592680 @default.
• W2942550960 hasConcept C24890656 @default.
• W2942550960 hasConcept C2776694085 @default.
• W2942550960 hasConcept C2778239845 @default.
• W2942550960 hasConcept C2778923194 @default.
• W2942550960 hasConcept C2780427987 @default.
• W2942550960 hasConcept C502942594 @default.
• W2942550960 hasConcept C54355233 @default.
• W2942550960 hasConcept C62478195 @default.
• W2942550960 hasConcept C62794011 @default.
• W2942550960 hasConcept C71924100 @default.
• W2942550960 hasConcept C86339819 @default.
• W2942550960 hasConcept C86803240 @default.
• W2942550960 hasConcept C95444343 @default.
• W2942550960 hasConceptScore W2942550960C104317684 @default.
• W2942550960 hasConceptScore W2942550960C121332964 @default.
• W2942550960 hasConceptScore W2942550960C121608353 @default.
• W2942550960 hasConceptScore W2942550960C123079801 @default.
• W2942550960 hasConceptScore W2942550960C126322002 @default.
• W2942550960 hasConceptScore W2942550960C143998085 @default.
• W2942550960 hasConceptScore W2942550960C185592680 @default.
• W2942550960 hasConceptScore W2942550960C24890656 @default.
• W2942550960 hasConceptScore W2942550960C2776694085 @default.
• W2942550960 hasConceptScore W2942550960C2778239845 @default.
• W2942550960 hasConceptScore W2942550960C2778923194 @default.
• W2942550960 hasConceptScore W2942550960C2780427987 @default.
• W2942550960 hasConceptScore W2942550960C502942594 @default.
• W2942550960 hasConceptScore W2942550960C54355233 @default.
• W2942550960 hasConceptScore W2942550960C62478195 @default.
• W2942550960 hasConceptScore W2942550960C62794011 @default.
• W2942550960 hasConceptScore W2942550960C71924100 @default.
• W2942550960 hasConceptScore W2942550960C86339819 @default.
• W2942550960 hasConceptScore W2942550960C86803240 @default.
• W2942550960 hasConceptScore W2942550960C95444343 @default.
• W2942550960 hasIssue "11" @default.
• W2942550960 hasLocation W29425509601 @default.
• W2942550960 hasOpenAccess W2942550960 @default.
• W2942550960 hasPrimaryLocation W29425509601 @default.

• next