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- W2942604310 abstract "Summary Recent evidence demonstrates that novel protein-coding genes can arise de novo from intergenic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of intergenic transcripts, which exposes a reservoir of variable polypeptides to natural selection. Do intergenic translation events yield polypeptides with useful biochemical capacities? The answer to this question remains controversial. Here, we systematically characterized how de novo emerging coding sequences impact fitness. In budding yeast, overexpression of these sequences was enriched in beneficial effects, while their disruption was generally inconsequential. We found that beneficial emerging sequences have a strong tendency to encode putative transmembrane proteins, which appears to stem from a cryptic propensity for transmembrane signals throughout thymine-rich intergenic regions of the genome. These findings suggest that novel genes with useful biochemical capacities, such as transmembrane domains, tend to evolve de novo within intergenic loci that already harbored a blueprint for these capacities." @default.
- W2942604310 created "2019-05-09" @default.
- W2942604310 creator A5004290985 @default.
- W2942604310 creator A5009811537 @default.
- W2942604310 creator A5010501935 @default.
- W2942604310 creator A5015212248 @default.
- W2942604310 creator A5021937219 @default.
- W2942604310 creator A5023869904 @default.
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- W2942604310 creator A5044343989 @default.
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- W2942604310 creator A5062629197 @default.
- W2942604310 creator A5069894429 @default.
- W2942604310 creator A5089373684 @default.
- W2942604310 date "2019-04-29" @default.
- W2942604310 modified "2023-09-28" @default.
- W2942604310 title "De novoemergence of adaptive membrane proteins from thymine-rich intergenic sequences" @default.
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