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- W2942689664 abstract "Mitochondrial DNA (mtDNA) content and telomere length are putative aging biomarkers and are sensitive to environmental stressors, including pollutants. Our objective was to identify, from a set of environmental exposures, which exposure is associated with leukocyte mtDNA content and telomere length in adults. This study includes 175 adults from 50 to 65 years old from the cross-sectional Flemish Environment and Health study, of whom leukocyte telomere length and mtDNA content were determined using qPCR. The levels of exposure of seven metals, 11 organohalogens, and four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS) were measured. We performed sparse partial least-squares regression analyses followed by ordinary least-squares regression to assess the multipollutant associations. While accounting for possible confounders and coexposures, we identified that urinary cadmium (6.52%, 95% confidence interval, 1.06, 12.28), serum hexachlorobenzene (2.89%, 018, 5.68), and perfluorooctanesulfonic acid (11.38%, 5.97, 17.08) exposure were positively associated (p < 0.05) with mtDNA content, while urinary copper (−9.88%, −14.82, −4.66) and serum perfluorohexanesulfonic acid (−4.75%, −8.79, −0.54) exposure were inversely associated with mtDNA content. Urinary antimony (2.69%, 0.45, 4.99) and mercury (1.91%, 0.42, 3.43) exposure were positively associated with leukocyte telomere length, while urinary copper (−3.52%, −6.60, −0.34) and serum perfluorooctanesulfonic acid (−3.64%, −6.60, −0.60) showed an inverse association. Our findings support the hypothesis that environmental pollutants interact with molecular hallmarks of aging." @default.
- W2942689664 created "2019-05-09" @default.
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- W2942689664 date "2019-05-01" @default.
- W2942689664 modified "2023-10-12" @default.
- W2942689664 title "Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach" @default.
- W2942689664 cites W104759472 @default.
- W2942689664 cites W119745193 @default.
- W2942689664 cites W1545819566 @default.
- W2942689664 cites W1965465659 @default.
- W2942689664 cites W1965806609 @default.
- W2942689664 cites W1967553734 @default.
- W2942689664 cites W1975364410 @default.
- W2942689664 cites W1976444718 @default.
- W2942689664 cites W1983950597 @default.
- W2942689664 cites W1986952822 @default.
- W2942689664 cites W1996815439 @default.
- W2942689664 cites W1998150842 @default.
- W2942689664 cites W2007564565 @default.
- W2942689664 cites W2011606516 @default.
- W2942689664 cites W2012221707 @default.
- W2942689664 cites W2015703383 @default.
- W2942689664 cites W2024721457 @default.
- W2942689664 cites W2026761826 @default.
- W2942689664 cites W2027794314 @default.
- W2942689664 cites W2032746255 @default.
- W2942689664 cites W2035844262 @default.
- W2942689664 cites W2038260949 @default.
- W2942689664 cites W2040254129 @default.
- W2942689664 cites W2040601774 @default.
- W2942689664 cites W2042377388 @default.
- W2942689664 cites W2047906382 @default.
- W2942689664 cites W2063931700 @default.
- W2942689664 cites W2064341136 @default.
- W2942689664 cites W2064563927 @default.
- W2942689664 cites W2065298316 @default.
- W2942689664 cites W2066976215 @default.
- W2942689664 cites W2068337326 @default.
- W2942689664 cites W2077438828 @default.
- W2942689664 cites W2083421615 @default.
- W2942689664 cites W2084654557 @default.
- W2942689664 cites W2087591041 @default.
- W2942689664 cites W2088628346 @default.
- W2942689664 cites W2093808264 @default.
- W2942689664 cites W2098898118 @default.
- W2942689664 cites W2103562463 @default.
- W2942689664 cites W2130272241 @default.
- W2942689664 cites W2138028307 @default.
- W2942689664 cites W2138625394 @default.
- W2942689664 cites W2140133214 @default.
- W2942689664 cites W2144896292 @default.
- W2942689664 cites W2153375305 @default.
- W2942689664 cites W2153461638 @default.
- W2942689664 cites W2154400571 @default.
- W2942689664 cites W2160185049 @default.
- W2942689664 cites W2170201161 @default.
- W2942689664 cites W2170917242 @default.
- W2942689664 cites W2209478088 @default.
- W2942689664 cites W2210328875 @default.
- W2942689664 cites W2230408745 @default.
- W2942689664 cites W2310723464 @default.
- W2942689664 cites W2314442617 @default.
- W2942689664 cites W2324161295 @default.
- W2942689664 cites W2326111428 @default.
- W2942689664 cites W2335224112 @default.
- W2942689664 cites W2347193990 @default.
- W2942689664 cites W2401468526 @default.
- W2942689664 cites W2462568970 @default.
- W2942689664 cites W2468100412 @default.
- W2942689664 cites W2472561123 @default.
- W2942689664 cites W2493256721 @default.
- W2942689664 cites W2497878991 @default.
- W2942689664 cites W2527049394 @default.
- W2942689664 cites W2529482334 @default.
- W2942689664 cites W2546215880 @default.
- W2942689664 cites W2550543927 @default.
- W2942689664 cites W2558457548 @default.
- W2942689664 cites W2569030249 @default.
- W2942689664 cites W2598521069 @default.
- W2942689664 cites W2612120761 @default.
- W2942689664 cites W2623863163 @default.
- W2942689664 cites W2752047448 @default.
- W2942689664 cites W2761047458 @default.
- W2942689664 cites W2768709269 @default.