FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942693939> ?p ?o ?g. }

• W2942693939 abstract "Depression is a heterogeneous mental illness with symptoms including sadness, helplessness, anhedonia, fatigue and suicidality. Based on its increasing prevalence, depression is predicted to be the second major cause of disability worldwide by 2020. Despite this fact, the aetio-pathophysiology of depression remains poorly understood. Human clinical and experimental studies have linked the inflammatory cytokine network with depressive symptoms, leading to the cytokine hypothesis of depression. However, the direction of the causal relationship between depression and the activation of the immune system, as well as the involved mediators and pathways, have not yet been clarified. Valid translational animal models are essential to investigate the hypothesis postulating that peripheral and central immune-activation, especially increased TNF, is induced by stress and effects neurobiological changes leading to depression. Several studies in rodents have investigated the effects of a single TNF application on behavior, but not of a prolonged TNF increase, although this would correspond more closely to the low, prolonged increase in plasma TNF observed in human depression. This PhD project provides insight into the differential effects of a prolonged increase of TNF in the periphery versus specific brain regions on behaviors that can be translated to symptoms or domains of depression. The main focus was placed on the reactivity to negative stimuli, as assessed by fear conditioning-expression and avoid-escape behavior, and on the reactivity to positive stimuli, as assessed by saccharin versus water consumption and preference. Repeated injection as well as continuous delivery of TNF in the periphery were investigated, and chronic elevation of TNF expression in specific brain regions, namely periventricular regions, amygdala and hippocampus were achieved using viral vectors. This project demonstrated in mice that peripheral increases in TNF resulted in moderate sickness, an increased reactivity to negative stimuli and a reduced reactivity to reward, effects that co-occurred with splenomegaly and increases in plasma IL-B6 and IL-B10 while not leading to glial activation. Central increase in TNF led to increased reactivity to negative stimuli when localized to periventricular regions of hippocampus, while increased amygdala TNF led to reduced reactivity to saccharin and did so in the absence of both sickness in terms of body weight loss and changes in the plasma levels of cytokines. These findings provide important new insights into the causal inter-relationships between peripheral TNF, central TNF and depression-relevant behavior and will inform research and development relevant to anti-inflammatory strategies of antidepressant treatment." @default.
• W2942693939 created "2019-05-09" @default.
• W2942693939 creator A5055013542 @default.
• W2942693939 date "2015-10-01" @default.
• W2942693939 modified "2023-09-25" @default.
• W2942693939 title "Studying the effects of increased tumor necrosis factor (TNF) in periphery versus specific brain regions on depression-relevant behavior and physiological markers in mice" @default.
• W2942693939 doi "https://doi.org/10.5167/uzh-120308" @default.
• W2942693939 hasPublicationYear "2015" @default.
• W2942693939 type Work @default.
• W2942693939 sameAs 2942693939 @default.
• W2942693939 citedByCount "0" @default.
• W2942693939 crossrefType "dissertation" @default.
• W2942693939 hasAuthorship W2942693939A5055013542 @default.
• W2942693939 hasConcept C118552586 @default.
• W2942693939 hasConcept C126322002 @default.
• W2942693939 hasConcept C139719470 @default.
• W2942693939 hasConcept C15744967 @default.
• W2942693939 hasConcept C162324750 @default.
• W2942693939 hasConcept C167305396 @default.
• W2942693939 hasConcept C169760540 @default.
• W2942693939 hasConcept C17991360 @default.
• W2942693939 hasConcept C203014093 @default.
• W2942693939 hasConcept C2776867660 @default.
• W2942693939 hasConcept C2778690821 @default.
• W2942693939 hasConcept C2778875871 @default.
• W2942693939 hasConcept C2778941446 @default.
• W2942693939 hasConcept C2779144063 @default.
• W2942693939 hasConcept C2779177272 @default.
• W2942693939 hasConcept C2780051608 @default.
• W2942693939 hasConcept C513476851 @default.
• W2942693939 hasConcept C558461103 @default.
• W2942693939 hasConcept C70410870 @default.
• W2942693939 hasConcept C71924100 @default.
• W2942693939 hasConcept C8891405 @default.
• W2942693939 hasConceptScore W2942693939C118552586 @default.
• W2942693939 hasConceptScore W2942693939C126322002 @default.
• W2942693939 hasConceptScore W2942693939C139719470 @default.
• W2942693939 hasConceptScore W2942693939C15744967 @default.
• W2942693939 hasConceptScore W2942693939C162324750 @default.
• W2942693939 hasConceptScore W2942693939C167305396 @default.
• W2942693939 hasConceptScore W2942693939C169760540 @default.
• W2942693939 hasConceptScore W2942693939C17991360 @default.
• W2942693939 hasConceptScore W2942693939C203014093 @default.
• W2942693939 hasConceptScore W2942693939C2776867660 @default.
• W2942693939 hasConceptScore W2942693939C2778690821 @default.
• W2942693939 hasConceptScore W2942693939C2778875871 @default.
• W2942693939 hasConceptScore W2942693939C2778941446 @default.
• W2942693939 hasConceptScore W2942693939C2779144063 @default.
• W2942693939 hasConceptScore W2942693939C2779177272 @default.
• W2942693939 hasConceptScore W2942693939C2780051608 @default.
• W2942693939 hasConceptScore W2942693939C513476851 @default.
• W2942693939 hasConceptScore W2942693939C558461103 @default.
• W2942693939 hasConceptScore W2942693939C70410870 @default.
• W2942693939 hasConceptScore W2942693939C71924100 @default.
• W2942693939 hasConceptScore W2942693939C8891405 @default.
• W2942693939 hasLocation W29426939391 @default.
• W2942693939 hasOpenAccess W2942693939 @default.
• W2942693939 hasPrimaryLocation W29426939391 @default.
• W2942693939 hasRelatedWork W1806118721 @default.
• W2942693939 hasRelatedWork W2009388360 @default.
• W2942693939 hasRelatedWork W2031946701 @default.
• W2942693939 hasRelatedWork W2034355214 @default.
• W2942693939 hasRelatedWork W2044404835 @default.
• W2942693939 hasRelatedWork W2115086834 @default.
• W2942693939 hasRelatedWork W2138933680 @default.
• W2942693939 hasRelatedWork W2142058476 @default.
• W2942693939 hasRelatedWork W2320181036 @default.
• W2942693939 hasRelatedWork W2326371726 @default.
• W2942693939 hasRelatedWork W2408044189 @default.
• W2942693939 hasRelatedWork W2902897427 @default.
• W2942693939 hasRelatedWork W2912271293 @default.
• W2942693939 hasRelatedWork W2965462752 @default.
• W2942693939 hasRelatedWork W2978753396 @default.
• W2942693939 hasRelatedWork W3021211165 @default.
• W2942693939 hasRelatedWork W3084721587 @default.
• W2942693939 hasRelatedWork W3212067477 @default.
• W2942693939 hasRelatedWork W850375225 @default.
• W2942693939 hasRelatedWork W2122892235 @default.
• W2942693939 isParatext "false" @default.
• W2942693939 isRetracted "false" @default.
• W2942693939 magId "2942693939" @default.
• W2942693939 workType "dissertation" @default.